# Space Kitty Archive

> Citation-verified research dossiers and a curated index of 16,224 frontier papers and trials across 66 topics, built for AI agents. Free search and previews; premium content costs $0.20 per request via the x402 protocol (USDC on Base Sepolia (testnet)). No accounts or API keys.

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## Domains and topics

### Artificial Intelligence
Frontier machine learning: large language models, reasoning, alignment, interpretability, agents, generative models, efficient inference and AI for science.

- [LLM Architectures & Pretraining](https://space-kitty.com/topics/llm-architectures): How frontier language models are built: transformer variants, mixture-of-experts, state-space and hybrid models, long-context attention, tokenization and pretraining recipes. (309 papers; dossier: https://space-kitty.com/dossiers/llm-architectures)
- [Scaling Laws & Compute-Optimal Training](https://space-kitty.com/topics/scaling-laws): Empirical laws relating loss and capability to parameters, data and compute; data-constrained and synthetic-data scaling; emergent abilities and their measurement. (205 papers)
- [Reasoning Models & Test-Time Compute](https://space-kitty.com/topics/reasoning-models): Chain-of-thought, reinforcement learning with verifiable rewards, process reward models and test-time scaling behind modern reasoning models. (233 papers)
- [AI Alignment & Safety](https://space-kitty.com/topics/alignment-safety): RLHF and its successors, constitutional and preference optimization methods, scalable oversight, dangerous-capability evaluations, reward hacking and deceptive behavior. (238 papers)
- [Mechanistic Interpretability](https://space-kitty.com/topics/interpretability): Reverse-engineering neural networks: superposition, sparse autoencoders and transcoders, circuits and attribution graphs, probing and activation steering. (234 papers)
- [LLM Agents & Tool Use](https://space-kitty.com/topics/ai-agents): Agents that plan and act: tool and function calling, computer-use and coding agents, multi-agent systems, agent benchmarks and agent protocols. (240 papers)
- [Generative & Multimodal Models](https://space-kitty.com/topics/generative-multimodal): Diffusion and flow-matching models, vision-language models, video generation and learned world models. (273 papers)
- [Efficient Training & Inference](https://space-kitty.com/topics/efficient-ai): Quantization, distillation, sparsity, speculative decoding, KV-cache compression and IO-aware kernels that make frontier models cheaper to train and serve. (253 papers)
- [AI for Science](https://space-kitty.com/topics/ai-for-science): Machine learning that accelerates discovery: protein structure, machine-learned force fields, materials discovery, weather and autonomous laboratories. (250 papers)
- [Robot Learning & Embodied AI](https://space-kitty.com/topics/robotics-embodied): Vision-language-action models, large-scale imitation learning, sim-to-real transfer, dexterous manipulation and humanoid control. (264 papers)

### Quantum Computing & Information
Fault-tolerant quantum computing, qubit hardware platforms, quantum algorithms, quantum networks, post-quantum cryptography and quantum sensing.

- [Quantum Error Correction & Fault Tolerance](https://space-kitty.com/topics/quantum-error-correction): Surface codes and qLDPC codes, below-threshold logical qubits, real-time decoding, magic-state distillation and cultivation, and resource estimates for fault tolerance. (279 papers; dossier: https://space-kitty.com/dossiers/quantum-error-correction)
- [Superconducting Quantum Processors](https://space-kitty.com/topics/superconducting-qubits): Transmon, fluxonium and bosonic cat qubits; coherence, gate fidelity, leakage, cosmic-ray errors, packaging and scaling of superconducting processors. (253 papers)
- [Neutral-Atom & Trapped-Ion Quantum Computing](https://space-kitty.com/topics/atoms-and-ions): Rydberg atom arrays, reconfigurable logical processors, QCCD trapped-ion architectures, high-fidelity gates and mid-circuit measurement. (242 papers)
- [Photonic, Spin & Topological Qubits](https://space-kitty.com/topics/photonic-topological-qubits): Photonic fusion-based architectures and GKP states, silicon spin qubits, and Majorana-based topological qubits including the evidence debate. (238 papers)
- [Quantum Algorithms & Quantum Advantage](https://space-kitty.com/topics/quantum-algorithms-advantage): Factoring and chemistry resource estimates, quantum simulation algorithms, random-circuit sampling, verifiable advantage and the classical-simulation counterattack. (182 papers)
- [Quantum Networks & Post-Quantum Cryptography](https://space-kitty.com/topics/quantum-communication-crypto): Quantum key distribution, repeaters and entanglement distribution, and the migration to NIST post-quantum standards (ML-KEM, ML-DSA, SLH-DSA). (254 papers)
- [Quantum Sensing & Metrology](https://space-kitty.com/topics/quantum-sensing): NV-center magnetometry, optical lattice and nuclear clocks, squeezed light in gravitational-wave detectors and atom interferometry. (219 papers)

### Fundamental & Quantum Physics
Quantum foundations, quantum many-body physics, topological matter, particle physics beyond the Standard Model, quantum gravity and gravitational waves.

- [Quantum Foundations](https://space-kitty.com/topics/quantum-foundations): Loophole-free Bell tests, the measurement problem, contextuality, Wigner's-friend scenarios and experimental tests of collapse models. (244 papers)
- [Quantum Many-Body Physics & Simulation](https://space-kitty.com/topics/many-body-quantum-simulation): Thermalization and its breakdown, many-body localization, quantum scars, discrete time crystals and analog quantum simulators. (219 papers)
- [Topological Phases & Anyons](https://space-kitty.com/topics/topological-matter): Topological insulators and semimetals, fractional Chern insulators, the fractional quantum anomalous Hall effect in moire materials and non-Abelian anyons. (249 papers)
- [Particle Physics & Beyond the Standard Model](https://space-kitty.com/topics/particle-physics-bsm): Higgs precision, the muon g-2 saga, neutrino masses and oscillations, flavor anomalies and collider searches for new physics. (231 papers)
- [Quantum Gravity & Holography](https://space-kitty.com/topics/quantum-gravity-holography): AdS/CFT, the black-hole information problem and islands, entanglement and the emergence of spacetime, and de Sitter quantum gravity. (248 papers)
- [Gravitational-Wave Astronomy](https://space-kitty.com/topics/gravitational-waves): LIGO-Virgo-KAGRA compact-binary catalogs, multimessenger neutron-star mergers, the nanohertz pulsar-timing background and tests of general relativity. (275 papers)

### Superconductivity & Quantum Materials
Mechanisms and materials of superconductivity: cuprates, nickelates, hydrides, moire systems, topological superconductors, applied HTS and computational discovery.

- [Cuprates & the Pairing Mechanism](https://space-kitty.com/topics/cuprate-mechanism): High-Tc cuprates, the Hubbard model and its numerics, the pseudogap, strange-metal transport, charge order and d-wave pairing. (235 papers)
- [Nickelate & Iron-Based Superconductors](https://space-kitty.com/topics/nickelates-iron-based): Infinite-layer and Ruddlesden-Popper nickelates (including La3Ni2O7 under pressure and ambient-pressure films) and iron pnictides and chalcogenides. (236 papers)
- [Superconducting Hydrides Under Pressure](https://space-kitty.com/topics/hydride-superconductors): H3S, LaH10 and ternary hydrides; diamond-anvil-cell measurement challenges, reproducibility disputes and the search for metastable low-pressure hydrides. (237 papers)
- [Room-Temperature Superconductivity Claims & Replication](https://space-kitty.com/topics/room-temperature-claims): High-profile claims (LK-99, retracted hydride papers) and replication efforts; the evidentiary standard of zero resistance plus a bulk Meissner effect. (232 papers)
- [Moire & 2D Superconductivity](https://space-kitty.com/topics/moire-superconductivity): Magic-angle graphene, twisted transition-metal dichalcogenides, rhombohedral multilayer graphene and chiral or unconventional 2D superconductivity. (245 papers)
- [Topological Superconductivity & Majorana Modes](https://space-kitty.com/topics/topological-superconductivity): Majorana zero modes in nanowires, Kitaev chains, vortex-bound states in iron-based materials and the reproducibility debate. (240 papers)
- [Applied Superconductivity & HTS Magnets](https://space-kitty.com/topics/applied-superconductivity): REBCO coated conductors, 20-tesla-class fusion magnets, MRI, power cables, superconducting RF cavities and superconducting electronics. (240 papers)
- [Computational & AI-Driven Superconductor Discovery](https://space-kitty.com/topics/superconductor-discovery): Ab initio Eliashberg predictions, machine-learning Tc models and high-throughput screening for new conventional and unconventional superconductors. (256 papers)

### Advanced Medicine
Clinical and translational frontiers: immunotherapy, mRNA and gene editing, gene and cell therapy, incretin drugs, neurodegeneration, aging, infectious disease, cardiovascular therapeutics and clinical AI.

- [Cancer Immunotherapy](https://space-kitty.com/topics/cancer-immunotherapy): Immune checkpoint inhibitors, CAR-T and TIL cell therapies including solid tumors, T-cell engagers and bispecifics, and antibody-drug conjugates. (288 papers)
- [mRNA Therapeutics & Cancer Vaccines](https://space-kitty.com/topics/mrna-cancer-vaccines): Personalized neoantigen mRNA vaccines, lipid-nanoparticle delivery, self-amplifying and circular RNA and mRNA therapeutics beyond infectious disease. (223 papers)
- [CRISPR & Gene-Editing Therapies](https://space-kitty.com/topics/gene-editing-therapies): Approved and investigational CRISPR-Cas9 therapies, base and prime editing, in vivo LNP-delivered editing and bespoke editing for ultra-rare disease. (264 papers)
- [Gene & Cell Therapy](https://space-kitty.com/topics/gene-cell-therapy): AAV and lentiviral gene therapy, in vivo CAR-T, iPSC- and stem-cell-derived replacement therapies such as islets and dopaminergic neurons. (232 papers)
- [GLP-1 & Incretin Therapies](https://space-kitty.com/topics/glp1-metabolic): Semaglutide, tirzepatide and next-generation incretin agonists; obesity, diabetes, cardiovascular, renal, liver and neuropsychiatric outcomes. (230 papers; dossier: https://space-kitty.com/dossiers/glp1-metabolic)
- [Alzheimer's, Parkinson's & Neurodegeneration](https://space-kitty.com/topics/neurodegeneration): Anti-amyloid antibodies, plasma p-tau biomarkers, alpha-synuclein seed amplification, antisense therapies for ALS and emerging disease-modifying strategies. (354 papers)
- [Biology of Aging & Longevity](https://space-kitty.com/topics/aging-longevity): Hallmarks of aging, senolytics, epigenetic clocks, partial reprogramming, mTOR and other geroprotective interventions. (305 papers)
- [Infectious Disease, Vaccines & Antimicrobial Resistance](https://space-kitty.com/topics/infectious-disease-amr): New antibiotic classes and AI-discovered antibiotics, phage therapy, long-acting HIV prevention and next-generation vaccines. (253 papers)
- [AI in Clinical Medicine](https://space-kitty.com/topics/ai-medicine): Validated diagnostic AI, medical large language models, AI-discovered drug candidates in clinical trials and evidence standards for clinical deployment. (254 papers)
- [Cardiovascular Therapeutics](https://space-kitty.com/topics/cardiovascular-innovation): Lipoprotein(a)-lowering drugs, siRNA and gene-editing approaches to LDL cholesterol, CETP inhibition and other cardiovascular advances. (252 papers)

### Biotechnology & Life Sciences
AI protein design, single-cell and spatial omics, synthetic biology and organoid systems.

- [AI Protein Design & Structure Prediction](https://space-kitty.com/topics/protein-design): AlphaFold and successors, diffusion-based protein design, inverse folding and de novo binders and enzymes. (323 papers)
- [Single-Cell & Spatial Omics](https://space-kitty.com/topics/single-cell-spatial): Single-cell atlases, spatial transcriptomics and proteomics, perturbation screens and foundation models of cells. (354 papers)
- [Synthetic Biology & Genome Engineering](https://space-kitty.com/topics/synthetic-biology): Synthetic genomes, genetic circuits, cell-free systems, genome writing and biomanufacturing, plus biosafety and governance considerations. (317 papers)
- [Organoids & Organ-on-Chip](https://space-kitty.com/topics/organoids): Brain and tissue organoids, assembloids, organ-on-chip platforms and their use in disease modeling and drug testing. (228 papers)

### Neuroscience & Brain-Computer Interfaces
Brain-computer interfaces, connectomics, NeuroAI and next-generation psychiatric therapeutics.

- [Brain-Computer Interfaces](https://space-kitty.com/topics/brain-computer-interfaces): Speech and handwriting neuroprostheses, high-channel-count intracortical arrays, endovascular and minimally invasive BCIs and closed-loop stimulation. (280 papers)
- [Connectomics & Brain Mapping](https://space-kitty.com/topics/connectomics): Whole-brain connectomes, cubic-millimeter cortical reconstructions, expansion microscopy and brain-wide cell atlases. (338 papers)
- [NeuroAI & Computational Neuroscience](https://space-kitty.com/topics/neuroai): Neural networks as models of the brain, predictive coding, neural population dynamics and foundation models trained on neural data. (227 papers)
- [Novel Psychiatric Therapeutics](https://space-kitty.com/topics/psychiatric-therapeutics): Psychedelic-assisted therapy, muscarinic antipsychotics, neurosteroids, rapid-acting antidepressants and accelerated neuromodulation. (359 papers)

### Fusion, Energy & Climate
Magnetic and inertial fusion, next-generation batteries and photovoltaics, AI weather and climate models, and carbon dioxide removal.

- [Magnetic Confinement Fusion](https://space-kitty.com/topics/magnetic-fusion): Tokamaks and stellarators, ITER, compact high-field devices, plasma confinement records and machine-learning plasma control. (246 papers)
- [Inertial Confinement Fusion](https://space-kitty.com/topics/inertial-fusion): Ignition and target gain at the National Ignition Facility, implosion physics and laser and pulsed-power drivers. (244 papers)
- [Next-Generation Batteries](https://space-kitty.com/topics/next-gen-batteries): Solid-state electrolytes, lithium-metal and silicon anodes, sodium-ion chemistries and machine-learning degradation prediction. (247 papers)
- [Perovskite & Tandem Photovoltaics](https://space-kitty.com/topics/advanced-photovoltaics): Perovskite solar-cell efficiency and stability, perovskite-silicon and all-perovskite tandems and scale-up. (249 papers)
- [AI Weather & Climate Modeling](https://space-kitty.com/topics/ai-weather-climate): Machine-learning weather prediction (GraphCast, GenCast, Aurora), hybrid climate models (NeuralGCM) and kilometer-scale simulation. (247 papers)
- [Carbon Dioxide Removal](https://space-kitty.com/topics/carbon-removal): Direct air capture sorbents and costs, enhanced rock weathering, ocean alkalinity enhancement and monitoring, reporting and verification. (97 papers)

### Materials & Nanotechnology
2D materials and heterostructures, semiconductor device frontiers, metamaterials and integrated photonics.

- [2D Materials & Van der Waals Heterostructures](https://space-kitty.com/topics/2d-materials): Graphene and transition-metal dichalcogenides, 2D magnets, moire excitons and van der Waals device engineering. (248 papers)
- [Semiconductor Device Frontiers](https://space-kitty.com/topics/semiconductor-frontiers): Gate-all-around and 2D-channel transistors, backside power delivery, advanced packaging and in-memory and neuromorphic hardware. (220 papers)
- [Metamaterials, Nanophotonics & Integrated Photonics](https://space-kitty.com/topics/metamaterials-photonics): Metasurfaces, thin-film lithium niobate, integrated photonic circuits and optical computing for AI. (239 papers)

### Astrophysics & Cosmology
Dark energy and cosmological tensions, JWST and the early universe, exoplanets and biosignatures, black holes and dark matter.

- [Dark Energy & Cosmological Tensions](https://space-kitty.com/topics/dark-energy-hubble-tension): DESI baryon acoustic oscillations and evolving dark energy hints, the Hubble tension, S8 and the status of Lambda-CDM. (233 papers)
- [JWST & the Early Universe](https://space-kitty.com/topics/early-universe-jwst): High-redshift galaxy discoveries, little red dots, early supermassive black holes and reionization as seen by JWST. (247 papers)
- [Exoplanets & Biosignatures](https://space-kitty.com/topics/exoplanets-biosignatures): JWST exoplanet atmospheres, temperate sub-Neptunes and rocky worlds, and the debate over claimed biosignature gases. (245 papers)
- [Black Holes & Event Horizon Imaging](https://space-kitty.com/topics/black-hole-physics): Event Horizon Telescope images of M87* and Sgr A*, polarization and spin measurements and black-hole ringdown tests. (238 papers)
- [Dark Matter Searches](https://space-kitty.com/topics/dark-matter): WIMP direct detection (LZ, XENONnT, PandaX), axion haloscopes, primordial black holes and astrophysical constraints. (253 papers)

### Mathematics & Theoretical Computer Science
AI for mathematics and formal proof, landmark results in pure mathematics, and algorithmic and complexity breakthroughs.

- [AI for Mathematics & Formal Proof](https://space-kitty.com/topics/ai-mathematics): Lean and Mathlib, autoformalization, neural theorem proving, olympiad-level systems and AI-assisted discovery in mathematics. (226 papers)
- [Landmark Results in Pure Mathematics](https://space-kitty.com/topics/landmark-math-results): Recent major theorems and their status: geometric Langlands, Kakeya in three dimensions, sphere packing, the unknotting-number additivity counterexample and more. (228 papers)
- [Algorithms & Complexity Breakthroughs](https://space-kitty.com/topics/algorithms-complexity): Almost-linear-time max flow, shortest paths beyond Dijkstra's sorting barrier, matrix multiplication exponent improvements and space-time simulation results. (192 papers)
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Space Kitty Archive · https://space-kitty.com · API: https://space-kitty.com/api/v1 · MCP: https://space-kitty.com/mcp · Premium: $0.20/request via x402 (Base Sepolia (testnet)). Metadata: arXiv (CC0), OpenAlex (CC0), Europe PMC (CC BY/CC0 works), ClinicalTrials.gov.