{"id":"doi:10.1002/advs.77968","kind":"article","title":"Topological Quantum Biomaterials Enable Pyroptosis-Senescence Coupling for Enhanced Colorectal Cancer Therapy","authors":["Chen Z","Mei K","Yang Y","Xu M","Dai X","Gu R","Zhou F","Wang C","Chang M","Huang Y","Chen Y"],"author_count":11,"year":2026,"published":"2026-09-30","venue":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","cited_by":0,"doi":"10.1002/advs.77968","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1002/advs.77968","archive_url":"https://space-kitty.com/papers/doi:10.1002/advs.77968","updated":null,"pmid":"42814474","pmcid":"PMC13626165","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC13626165/pdf","abstract":"Inducing pyroptosis in tumor cells has emerged as a promising anticancer strategy. However, under sublethal oxidative stress, a considerable fraction of cancer cells evades pyroptosis and undergoes therapy-induced senescence, which ultimately drives chronic inflammation and facilitates tumor relapse. Here, we report an ultrasound-responsive sequential therapeutic strategy that orchestrates the pyroptosis-senescence axis for improved colorectal cancer therapy. This sequential therapeutic strategy integrates two functional modules, including morphologically engineered Pd 3 Sn topological quantum biomaterials and senolytic agent piperlongumine. Upon ultrasound irradiation, the tailored Pd 3 Sn nanostructures generate reactive oxygen species, which subsequently trigger zDHHC5-mediated S-acylation of gasdermin D, thereby initiating pyroptosis in colorectal cancer cells. Benefiting from its facet dependent near Fermi level electronic states and favorable peroxide activation kinetics, Pd 3 Sn achieves substantially improved sonocatalytic performance, allowing for the controlled production of radicals and the accurate triggering of the pyroptosis cascade. Intriguingly, the senescence-associated secretory phenotype factors released from pyroptotic cells drive the surviving cancer cells into a senescent state. These senescent cells are then selectively eliminated by piperlongumine, effectively abrogating their senescence-associated pro-tumorigenic effects. In subcutaneous and liver metastasis models, this nanoplatform significantly suppresses tumor progression, achieving an 83.4% tumor volume inhibition rate and minimal liver metastatic burden. This work opens the application of quantum biomaterials in biomedicine and establishes a new therapeutic paradigm for disease treatment.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"Topological Quantum Biomaterials Enable Pyroptosis-Senescence Coupling for Enhanced Colorectal Cancer Therapy\" by Chen Z, Mei K, Yang Y et al., https://doi.org/10.1002/advs.77968, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"aging-longevity","name":"Biology of Aging & Longevity","domain_slug":"medicine"}],"cited_in_dossiers":[]}