{"id":"doi:10.1007/s00415-023-12148-5","kind":"article","title":"Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort","authors":["Mendes AJ","Ribaldi F","Lathuiliere A","Ashton NJ","Janelidze S","Zetterberg H","Scheffler M","Assal F","Garibotto V","Blennow K","Hansson O","Frisoni GB"],"author_count":12,"year":2024,"published":"2024-01-09","venue":"Journal of neurology","cited_by":93,"doi":"10.1007/s00415-023-12148-5","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1007/s00415-023-12148-5","archive_url":"https://space-kitty.com/papers/doi:10.1007/s00415-023-12148-5","updated":null,"pmid":"38195896","pmcid":"PMC10972950","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC10972950/pdf","abstract":"Background and objective Phosphorylated tau (p-tau) 217 has recently received attention because it seems more reliable than other p-tau variants for identifying Alzheimer's disease (AD) pathology. Thus, we aimed to compare the diagnostic accuracy of plasma and CSF p-tau217 with p-tau181 and p-tau231 in a memory clinic cohort. Methods The study included 114 participants (CU = 33; MCI = 67; Dementia = 14). The p-tau variants were correlated versus continuous measures of amyloid (A) and tau (T)-PET. The p-tau phospho-epitopes were assessed through: (i) effect sizes (δ) between diagnostic and A ± and T ± groups; (ii) receiver operating characteristic (ROC) analyses in A-PET and T-PET. Results The correlations between both plasma and CSF p-tau217 with A-PET and T-PET (r range 0.64-0.83) were stronger than those of p-tau181 (r range 0.44-0.79) and p-tau231 (r range 0.46-0.76). Plasma p-tau217 showed significantly higher diagnostic accuracy than p-tau181 and p-tau231 in (i) differences between diagnostic and biomarker groups (δ range : p-tau217 = 0.55-0.96; p-tau181 = 0.51-0.67; p-tau231 = 0.53-0.71); (ii) ROC curves to identify A-PET and T-PET positivity (AUC average : p-tau217 = 0.96; p-tau181 = 0.76; p-tau231 = 0.79). On the other hand, CSF p-tau217 (AUC average = 0.95) did not reveal significant differences in A-PET and T-PET AUC than p-tau181 (AUC average = 0.88) and p-tau231 (AUC average = 0.89). Discussion Plasma p-tau217 demonstrated better performance in the identification of AD pathology and clinical phenotypes in comparison with other variants of p-tau in a memory clinic cohort. Furthermore, p-tau217 had comparable performance in plasma and CSF. Our findings suggest the potential of plasma p-tau217 in the diagnosis and screening for AD, which could allow for a decreased use of invasive biomarkers in the future.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort\" by Mendes AJ, Ribaldi F, Lathuiliere A et al., https://doi.org/10.1007/s00415-023-12148-5, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"neurodegeneration","name":"Alzheimer's, Parkinson's & Neurodegeneration","domain_slug":"medicine"}],"cited_in_dossiers":[]}