{"id":"doi:10.1016/j.mib.2018.04.004","kind":"review","title":"Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria","authors":["Wyres KL","Holt KE"],"author_count":2,"year":2018,"published":"2018-05-01","venue":"Current opinion in microbiology","cited_by":454,"doi":"10.1016/j.mib.2018.04.004","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1016/j.mib.2018.04.004","archive_url":"https://space-kitty.com/papers/doi:10.1016/j.mib.2018.04.004","updated":null,"pmid":"29723841","pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant clinical problem in its own right, K. pneumoniae is the species within which several new AMR genes were first discovered before spreading to other pathogens (e.g. carbapenem-resistance genes KPC, OXA-48 and NDM-1). Whilst K. pneumoniae's contribution to the overall AMR crisis is impossible to quantify, current evidence suggests it has a wider ecological distribution, significantly more varied DNA composition, greater AMR gene diversity and a higher plasmid burden than other Gram negative opportunists. Hence we propose it plays a key role in disseminating AMR genes from environmental microbes to clinically important pathogens.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":false,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria\" by Wyres KL, Holt KE, https://doi.org/10.1016/j.mib.2018.04.004, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"infectious-disease-amr","name":"Infectious Disease, Vaccines & Antimicrobial Resistance","domain_slug":"medicine"}],"cited_in_dossiers":[]}