{"id":"doi:10.1016/j.schres.2016.07.014","kind":"review","title":"The dysconnection hypothesis (2016)","authors":["Friston K","Brown HR","Siemerkus J","Stephan KE"],"author_count":4,"year":2016,"published":"2016-07-20","venue":"Schizophrenia research","cited_by":476,"doi":"10.1016/j.schres.2016.07.014","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1016/j.schres.2016.07.014","archive_url":"https://space-kitty.com/papers/doi:10.1016/j.schres.2016.07.014","updated":null,"pmid":"27450778","pmcid":"PMC5147460","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC5147460/pdf","abstract":"Twenty years have passed since the dysconnection hypothesis was first proposed (Friston and Frith, 1995; Weinberger, 1993). In that time, neuroscience has witnessed tremendous advances: we now live in a world of non-invasive neuroanatomy, computational neuroimaging and the Bayesian brain. The genomics era has come and gone. Connectomics and large-scale neuroinformatics initiatives are emerging everywhere. So where is the dysconnection hypothesis now? This article considers how the notion of schizophrenia as a dysconnection syndrome has developed - and how it has been enriched by recent advances in clinical neuroscience. In particular, we examine the dysconnection hypothesis in the context of (i) theoretical neurobiology and computational psychiatry; (ii) the empirical insights afforded by neuroimaging and associated connectomics - and (iii) how bottom-up (molecular biology and genetics) and top-down (systems biology) perspectives are converging on the mechanisms and nature of dysconnections in schizophrenia.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"The dysconnection hypothesis (2016)\" by Friston K, Brown HR, Siemerkus J et al., https://doi.org/10.1016/j.schres.2016.07.014, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"connectomics","name":"Connectomics & Brain Mapping","domain_slug":"neuroscience"}],"cited_in_dossiers":[]}