{"id":"doi:10.1038/ncomms14617","kind":"article","title":"DNA methylation signatures in peripheral blood strongly predict all-cause mortality","authors":["Zhang Y","Wilson R","Heiss J","Breitling LP","Saum KU","Schöttker B","Holleczek B","Waldenberger M","Peters A","Brenner H"],"author_count":10,"year":2017,"published":"2017-03-17","venue":"Nature communications","cited_by":312,"doi":"10.1038/ncomms14617","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1038/ncomms14617","archive_url":"https://space-kitty.com/papers/doi:10.1038/ncomms14617","updated":null,"pmid":"28303888","pmcid":"PMC5357865","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC5357865/pdf","abstract":"DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we performed epigenome-wide screening and validation to identify mortality-related DNAm signatures in a general population-based cohort with up to 14 years follow-up. In the discovery panel in a case-cohort approach, 11,063 CpGs reach genome-wide significance (FDR<0.05). 58 CpGs, mapping to 38 well-known disease-related genes and 14 intergenic regions, are confirmed in a validation panel. A mortality risk score based on ten selected CpGs exhibits strong association with all-cause mortality, showing hazard ratios (95% CI) of 2.16 (1.10-4.24), 3.42 (1.81-6.46) and 7.36 (3.69-14.68), respectively, for participants with scores of 1, 2-5 and 5+ compared with a score of 0. These associations are confirmed in an independent cohort and are independent from the 'epigenetic clock'. In conclusion, DNAm of multiple disease-related genes are strongly linked to mortality outcomes. The DNAm-based risk score might be informative for risk assessment and stratification.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"DNA methylation signatures in peripheral blood strongly predict all-cause mortality\" by Zhang Y, Wilson R, Heiss J et al., https://doi.org/10.1038/ncomms14617, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"aging-longevity","name":"Biology of Aging & Longevity","domain_slug":"medicine"}],"cited_in_dossiers":[]}