{"id":"doi:10.1038/s41467-019-08944-1","kind":"article","title":"Atypical functional connectome hierarchy in autism","authors":["Hong SJ","Vos de Wael R","Bethlehem RAI","Lariviere S","Paquola C","Valk SL","Milham MP","Di Martino A","Margulies DS","Smallwood J","Bernhardt BC"],"author_count":11,"year":2019,"published":"2019-03-04","venue":"Nature communications","cited_by":460,"doi":"10.1038/s41467-019-08944-1","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1038/s41467-019-08944-1","archive_url":"https://space-kitty.com/papers/doi:10.1038/s41467-019-08944-1","updated":null,"pmid":"30833582","pmcid":"PMC6399265","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC6399265/pdf","abstract":"One paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-cognitive processing. Here, we examined whether these phenotypical patterns may relate to an overarching system-level imbalance-specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. Combining connectome gradient and stepwise connectivity analysis based on task-free functional magnetic resonance imaging (fMRI), we demonstrated atypical connectivity transitions between sensory and higher-order default mode regions in a large cohort of individuals with autism relative to typically-developing controls. Further analyses indicated that reduced differentiation related to perturbed stepwise connectivity from sensory towards transmodal areas, as well as atypical long-range rich-club connectivity. Supervised pattern learning revealed that hierarchical features predicted deficits in social cognition and low-level behavioral symptoms, but not communication-related symptoms. Our findings provide new evidence for imbalances in network hierarchy in autism, which offers a parsimonious reference frame to consolidate its diverse features.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"Atypical functional connectome hierarchy in autism\" by Hong SJ, Vos de Wael R, Bethlehem RAI et al., https://doi.org/10.1038/s41467-019-08944-1, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"connectomics","name":"Connectomics & Brain Mapping","domain_slug":"neuroscience"}],"cited_in_dossiers":[]}