{"id":"doi:10.1038/s41467-020-15436-0","kind":"article","title":"Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease","authors":["Janelidze S","Stomrud E","Smith R","Palmqvist S","Mattsson N","Airey DC","Proctor NK","Chai X","Shcherbinin S","Sims JR","Triana-Baltzer G","Theunis C","Slemmon R","Mercken M","Kolb H","Dage JL","Hansson O"],"author_count":17,"year":2020,"published":"2020-04-03","venue":"Nature communications","cited_by":388,"doi":"10.1038/s41467-020-15436-0","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1038/s41467-020-15436-0","archive_url":"https://space-kitty.com/papers/doi:10.1038/s41467-020-15436-0","updated":null,"pmid":"32246036","pmcid":"PMC7125218","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC7125218/pdf","abstract":"Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer's disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort (n = 194), p-tau217 shows stronger correlations with the tau positron emission tomography (PET) tracer [ 18 F]flortaucipir, and more accurately identifies individuals with abnormally increased [ 18 F]flortaucipir retention. Furthermore, longitudinal increases in p-tau217 are higher compared to p-tau181 and better correlate with [ 18 F]flortaucipir uptake. P-tau217 correlates better than p-tau181 with CSF and PET measures of neocortical amyloid-β burden and more accurately distinguishes AD dementia from non-AD neurodegenerative disorders. Higher correlations between p-tau217 and [ 18 F]flortaucipir are corroborated in an independent EXPEDITION3 trial cohort (n = 32). The main results are validated using a different p-tau217 immunoassay. These findings suggest that p-tau217 might be more useful than p-tau181 in the diagnostic work up of AD.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease\" by Janelidze S, Stomrud E, Smith R et al., https://doi.org/10.1038/s41467-020-15436-0, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"neurodegeneration","name":"Alzheimer's, Parkinson's & Neurodegeneration","domain_slug":"medicine"}],"cited_in_dossiers":[]}