{"id":"doi:10.1038/s41467-021-25453-2","kind":"article","title":"Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice","authors":["Novais EJ","Tran VA","Johnston SN","Darris KR","Roupas AJ","Sessions GA","Shapiro IM","Diekman BO","Risbud MV"],"author_count":9,"year":2021,"published":"2021-09-03","venue":"Nature communications","cited_by":376,"doi":"10.1038/s41467-021-25453-2","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1038/s41467-021-25453-2","archive_url":"https://space-kitty.com/papers/doi:10.1038/s41467-021-25453-2","updated":null,"pmid":"34480023","pmcid":"PMC8417260","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC8417260/pdf","abstract":"Intervertebral disc degeneration is highly prevalent within the elderly population and is a leading cause of chronic back pain and disability. Due to the link between disc degeneration and senescence, we explored the ability of the Dasatinib and Quercetin drug combination (D + Q) to prevent an age-dependent progression of disc degeneration in mice. We treated C57BL/6 mice beginning at 6, 14, and 18 months of age, and analyzed them at 23 months of age. Interestingly, 6- and 14-month D + Q cohorts show lower incidences of degeneration, and the treatment results in a significant decrease in senescence markers p16 INK4a , p19 ARF , and SASP molecules IL-6 and MMP13. Treatment also preserves cell viability, phenotype, and matrix content. Although transcriptomic analysis shows disc compartment-specific effects of the treatment, cell death and cytokine response pathways are commonly modulated across tissue types. Results suggest that senolytics may provide an attractive strategy to mitigating age-dependent disc degeneration.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice\" by Novais EJ, Tran VA, Johnston SN et al., https://doi.org/10.1038/s41467-021-25453-2, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"aging-longevity","name":"Biology of Aging & Longevity","domain_slug":"medicine"}],"cited_in_dossiers":[]}