{"id":"doi:10.1038/s41467-022-29640-7","kind":"article","title":"A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance","authors":["Filo M","Kumar S","Khammash M"],"author_count":3,"year":2022,"published":"2022-04-19","venue":"Nature communications","cited_by":37,"doi":"10.1038/s41467-022-29640-7","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1038/s41467-022-29640-7","archive_url":"https://space-kitty.com/papers/doi:10.1038/s41467-022-29640-7","updated":null,"pmid":"35440114","pmcid":"PMC9018779","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC9018779/pdf","abstract":"Proportional-Integral-Derivative (PID) feedback controllers are the most widely used controllers in industry. Recently, the design of molecular PID-controllers has been identified as an important goal for synthetic biology and the field of cybergenetics. In this paper, we consider the realization of PID-controllers via biomolecular reactions. We propose an array of topologies offering a compromise between simplicity and high performance. We first demonstrate that different biomolecular PI-controllers exhibit different performance-enhancing capabilities. Next, we introduce several derivative controllers based on incoherent feedforward loops acting in a feedback configuration. Alternatively, we show that differentiators can be realized by placing molecular integrators in a negative feedback loop, which can be augmented by PI-components to yield PID-controllers. We demonstrate that PID-controllers can enhance stability and dynamic performance, and can also reduce stochastic noise. Finally, we provide an experimental demonstration using a hybrid setup where in silico PID-controllers regulate a genetic circuit in single yeast cells.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"A hierarchy of biomolecular proportional-integral-derivative feedback controllers for robust perfect adaptation and dynamic performance\" by Filo M, Kumar S, Khammash M, https://doi.org/10.1038/s41467-022-29640-7, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"synthetic-biology","name":"Synthetic Biology & Genome Engineering","domain_slug":"biotech"}],"cited_in_dossiers":[]}