{"id":"doi:10.1038/s41467-023-36774-9","kind":"article","title":"MicroRNA156 conditions auxin sensitivity to enable growth plasticity in response to environmental changes in Arabidopsis","authors":["Sang Q","Fan L","Liu T","Qiu Y","Du J","Mo B","Chen M","Chen X"],"author_count":8,"year":2023,"published":"2023-03-22","venue":"Nature communications","cited_by":28,"doi":"10.1038/s41467-023-36774-9","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1038/s41467-023-36774-9","archive_url":"https://space-kitty.com/papers/doi:10.1038/s41467-023-36774-9","updated":null,"pmid":"36949101","pmcid":"PMC10033679","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC10033679/pdf","abstract":"MicroRNAs (miRNAs) play diverse roles in plant development, but whether and how miRNAs participate in thermomorphogenesis remain ambiguous. Here we show that HYPONASTIC LEAVES 1 (HYL1)-a key component of miRNA biogenesis-acts downstream of the thermal regulator PHYTOCHROME INTERACTING FACTOR 4 in the temperature-dependent plasticity of hypocotyl growth in Arabidopsis. A hyl1-2 suppressor screen identified a dominant dicer-like1 allele that rescues hyl1-2's defects in miRNA biogenesis and thermoresponsive hypocotyl elongation. Genome-wide miRNA and transcriptome analysis revealed microRNA156 (miR156) and its target SQUAMOSA PROMOTER-BINDING-PROTEIN-LIKE 9 (SPL9) to be critical regulators of thermomorphogenesis. Surprisingly, perturbation of the miR156/SPL9 module disengages seedling responsiveness to warm temperatures by impeding auxin sensitivity. Moreover, miR156-dependent auxin sensitivity also operates in the shade avoidance response at lower temperatures. Thus, these results unveil the miR156/SPL9 module as a previously uncharacterized genetic circuit that enables plant growth plasticity in response to environmental temperature and light changes.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"MicroRNA156 conditions auxin sensitivity to enable growth plasticity in response to environmental changes in Arabidopsis\" by Sang Q, Fan L, Liu T et al., https://doi.org/10.1038/s41467-023-36774-9, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"synthetic-biology","name":"Synthetic Biology & Genome Engineering","domain_slug":"biotech"}],"cited_in_dossiers":[]}