{"id":"doi:10.1093/bioinformatics/btac749","kind":"article","title":"AlphaPulldown-a python package for protein-protein interaction screens using AlphaFold-Multimer","authors":["Yu D","Chojnowski G","Rosenthal M","Kosinski J"],"author_count":4,"year":2023,"published":"2023-01-01","venue":"Bioinformatics (Oxford, England)","cited_by":177,"doi":"10.1093/bioinformatics/btac749","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1093/bioinformatics/btac749","archive_url":"https://space-kitty.com/papers/doi:10.1093/bioinformatics/btac749","updated":null,"pmid":"36413069","pmcid":"PMC9805587","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC9805587/pdf","abstract":"Summary The artificial intelligence-based structure prediction program AlphaFold-Multimer enabled structural modelling of protein complexes with unprecedented accuracy. Increasingly, AlphaFold-Multimer is also used to discover new protein-protein interactions (PPIs). Here, we present AlphaPulldown, a Python package that streamlines PPI screens and high-throughput modelling of higher-order oligomers using AlphaFold-Multimer. It provides a convenient command-line interface, a variety of confidence scores and a graphical analysis tool. Availability and implementation AlphaPulldown is freely available at https://www.embl-hamburg.de/AlphaPulldown. Supplementary information Supplementary note is available at Bioinformatics online.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"AlphaPulldown-a python package for protein-protein interaction screens using AlphaFold-Multimer\" by Yu D, Chojnowski G, Rosenthal M et al., https://doi.org/10.1093/bioinformatics/btac749, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"protein-design","name":"AI Protein Design & Structure Prediction","domain_slug":"biotech"}],"cited_in_dossiers":[]}