{"id":"doi:10.1126/science.abo0510","kind":"article","title":"Mapping the developing human immune system across organs","authors":["Suo C","Dann E","Goh I","Jardine L","Kleshchevnikov V","Park JE","Botting RA","Stephenson E","Engelbert J","Tuong ZK","Polanski K","Yayon N","Xu C","Suchanek O","Elmentaite R","Domínguez Conde C","He P","Pritchard S","Miah M","Moldovan C","Steemers AS","Mazin P","Prete M","Horsfall D","Marioni JC"],"author_count":28,"year":2022,"published":"2022-06-03","venue":"Science (New York, N.Y.)","cited_by":295,"doi":"10.1126/science.abo0510","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1126/science.abo0510","archive_url":"https://space-kitty.com/papers/doi:10.1126/science.abo0510","updated":null,"pmid":"35549310","pmcid":"PMC7612819","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC7612819/pdf","abstract":"Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues combining single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics to reconstruct the developing human immune system. This revealed the late acquisition of immune-effector functions by myeloid and lymphoid cell subsets and the maturation of monocytes and T cells before peripheral tissue seeding. Moreover, we uncovered system-wide blood and immune cell development beyond primary hematopoietic organs, characterized human prenatal B1 cells, and shed light on the origin of unconventional T cells. Our atlas provides both valuable data resources and biological insights that will facilitate cell engineering, regenerative medicine, and disease understanding.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"Mapping the developing human immune system across organs\" by Suo C, Dann E, Goh I et al., https://doi.org/10.1126/science.abo0510, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"single-cell-spatial","name":"Single-Cell & Spatial Omics","domain_slug":"biotech"}],"cited_in_dossiers":[]}