{"id":"doi:10.1186/s40364-020-00228-x","kind":"review","title":"Roles of IFN-γ in tumor progression and regression: a review","authors":["Dragica Jorgovanović","Mengjia Song","Liping Wang","Yi Zhang"],"author_count":4,"year":2020,"published":"2020-09-29","venue":"Biomarker Research","cited_by":1233,"doi":"10.1186/s40364-020-00228-x","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1186/s40364-020-00228-x","archive_url":"https://space-kitty.com/papers/doi:10.1186/s40364-020-00228-x","updated":null,"pmid":"33005420","pmcid":null,"openalex_id":"W3090386083","pdf_url":"https://biomarkerres.biomedcentral.com/track/pdf/10.1186/s40364-020-00228-x","abstract":"BACKGROUND: Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro-apoptotic and antiproliferative functions, IFN-γ is considered potentially useful for adjuvant immunotherapy for different types of cancer. Moreover, it IFN-γ may inhibit angiogenesis in tumor tissue, induce regulatory T-cell apoptosis, and/or stimulate the activity of M1 proinflammatory macrophages to overcome tumor progression. However, the current understanding of the roles of IFN-γ in the tumor microenvironment (TME) may be misleading in terms of its clinical application. MAIN BODY: Some researchers believe it has anti-tumorigenic properties, while others suggest that it contributes to tumor growth and progression. In our recent work, we have shown that concentration of IFN-γ in the TME determines its function. Further, it was reported that tumors treated with low-dose IFN-γ acquired metastatic properties while those infused with high dose led to tumor regression. Pro-tumorigenic role may be described through IFN-γ signaling insensitivity, downregulation of major histocompatibility complexes, upregulation of indoleamine 2,3-dioxygenase, and checkpoint inhibitors such as programmed cell death ligand 1. CONCLUSION: Significant research efforts are required to decipher IFN-γ-dependent pro- and anti-tumorigenic effects. This review discusses the current knowledge concerning the roles of IFN-γ in the TME as a part of the complex immune response to cancer and highlights the importance of identifying IFN-γ responsive patients to improve their sensitivity to immuno-therapies.","abstract_license":"CC-BY (publisher license, via OpenAlex)","license":"cc-by","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Cancer Immunotherapy and Biomarkers"],"details":null,"provenance":"openalex","attribution":"Abstract of \"Roles of IFN-γ in tumor progression and regression: a review\" by Dragica Jorgovanović, Mengjia Song, Liping Wang et al., https://doi.org/10.1186/s40364-020-00228-x, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"cancer-immunotherapy","name":"Cancer Immunotherapy","domain_slug":"medicine"}],"cited_in_dossiers":[]}