{"id":"doi:10.1186/s40478-021-01307-2","kind":"article","title":"Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels","authors":["Wennström M","Janelidze S","Nilsson KPR","Serrano GE","Beach TG","Dage JL","Hansson O"],"author_count":7,"year":2022,"published":"2022-01-06","venue":"Acta neuropathologica communications","cited_by":66,"doi":"10.1186/s40478-021-01307-2","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.1186/s40478-021-01307-2","archive_url":"https://space-kitty.com/papers/doi:10.1186/s40478-021-01307-2","updated":null,"pmid":"34991721","pmcid":"PMC8734209","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC8734209/pdf","abstract":"Recent studies highlight phosphorylated tau (p-tau) at threonine tau 217 (p-tau217) as a new promising plasma biomarker for pathological changes implicated in Alzheimer's disease (AD), but the specific brain pathological events related to the alteration in p-tau217 plasma levels are still largely unknown. Using immunostaining techniques of postmortem AD brain tissue, we show that p-tau217 is found in neurofibrillary tangles (NFTs) and neuropil threads that are also positive for p-tau181, 202, 202/205, 231, and 369/404. The p-tau217, but not the other five p-tau variants, was also prominently seen in vesicles structure positive for markers of granulovacuolar degeneration bodies and multi-vesicular bodies. Further, individuals with a high likelihood of AD showed significantly higher p-tau217 area fraction in 4 different brain areas (entorhinal cortex, inferior temporal gyrus, and superior frontal gyrus) compared to those with Primary age related tauopathy or other non-AD tauopathies. The p-tau217 area fraction correlated strongly with total amyloid-beta (Aβ) and NFT brain load when the whole group was analyzed. Finally, the mean p-tau217 area fraction correlated significantly with p-tau217 concentrations in antemortem collected plasma specifically in individuals with amyloid plaques and not in those without amyloid plaques. These studies highlight differences in cellular localization of different p-tau variants and suggest that plasma levels of p-tau217 reflect an accumulation of p-tau217 in presence of Aβ plaque load.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels\" by Wennström M, Janelidze S, Nilsson KPR et al., https://doi.org/10.1186/s40478-021-01307-2, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"neurodegeneration","name":"Alzheimer's, Parkinson's & Neurodegeneration","domain_slug":"medicine"}],"cited_in_dossiers":[]}