{"id":"doi:10.15252/emmm.202114022","kind":"article","title":"Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau","authors":["Mattsson-Carlgren N","Janelidze S","Bateman RJ","Smith R","Stomrud E","Serrano GE","Reiman EM","Palmqvist S","Dage JL","Beach TG","Hansson O"],"author_count":11,"year":2021,"published":"2021-05-05","venue":"EMBO molecular medicine","cited_by":236,"doi":"10.15252/emmm.202114022","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.15252/emmm.202114022","archive_url":"https://space-kitty.com/papers/doi:10.15252/emmm.202114022","updated":null,"pmid":"33949133","pmcid":"PMC8185545","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC8185545/pdf","abstract":"Alzheimer's disease is characterized by β-amyloid plaques and tau tangles. Plasma levels of phospho-tau217 (P-tau217) accurately differentiate Alzheimer's disease dementia from other dementias, but it is unclear to what degree this reflects β-amyloid plaque accumulation, tau tangle accumulation, or both. In a cohort with post-mortem neuropathological data (N = 88), both plaque and tangle density contributed independently to higher P-tau217, but P-tau217 was not elevated in patients with non-Alzheimer's disease tauopathies (N = 9). Several findings were replicated in a cohort with PET imaging (\"BioFINDER-2\", N = 426), where β-amyloid and tau PET were independently associated with P-tau217. P-tau217 concentrations correlated with β-amyloid PET (but not tau PET) in early disease stages and with both β-amyloid and (more strongly) tau PET in late disease stages. Finally, P-tau217 mediated the association between β-amyloid and tau in both cohorts, especially for tau outside of the medial temporal lobe. These findings support the hypothesis that plasma P-tau217 concentration is increased by both β-amyloid plaques and tau tangles and is congruent with the hypothesis that P-tau is involved in β-amyloid-dependent formation of neocortical tau tangles.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau\" by Mattsson-Carlgren N, Janelidze S, Bateman RJ et al., https://doi.org/10.15252/emmm.202114022, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"neurodegeneration","name":"Alzheimer's, Parkinson's & Neurodegeneration","domain_slug":"medicine"}],"cited_in_dossiers":[]}