{"id":"doi:10.4103/nrr.nrronline-d-26-00800","kind":"article","title":"Crosstalk between exosomes and cellular senescence: A core vicious loop promoting α-synuclein pathology in Parkinson's disease","authors":["Mao W","Song W","Zhang Y","Feng W","Wang H","Cheng B"],"author_count":6,"year":2026,"published":"2026-09-30","venue":"Neural regeneration research","cited_by":0,"doi":"10.4103/nrr.nrronline-d-26-00800","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.4103/nrr.nrronline-d-26-00800","archive_url":"https://space-kitty.com/papers/doi:10.4103/nrr.nrronline-d-26-00800","updated":null,"pmid":"42821418","pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"Abstract Parkinson's disease is characterized by α-synuclein aggregation, dopaminergic neuron loss, and neuroinflammation. Emerging evidence reveals complex crosstalk between exosomes and cellular senescence in Parkinson's disease pathogenesis. Exosomes mediate α-synuclein transmission and neuroinflammation, while delivering protective factors such as miRNAs that inhibit cellular senescence. Senescent cells secrete pro-inflammatory factors via mitochondrial dysfunction and the senescence-associated secretory phenotype, linking to Parkinson's disease mitophagy defects. This forms a vicious \"senescence-protein deposition-inflammation\" cycle, with senescent cell-derived exosomes exacerbating α-synuclein aggregation and inflammation. Therapeutically, exosomes are ideal drug carriers due to blood-brain barrier penetrability and low immunogenicity for targeted antioxidant delivery. Future perspectives highlight exosome-based biomarkers and brain-gut axis intervention as promising directions. We propose integrating exosome engineering and senolytic strategies to lay the foundation for early diagnosis and precision therapy of Parkinson's disease, promoting diagnosis-intervention translational research and bridging bench-tobedside translation.","abstract_license":"CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC-BY","is_open_access":false,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Abstract of \"Crosstalk between exosomes and cellular senescence: A core vicious loop promoting α-synuclein pathology in Parkinson's disease\" by Mao W, Song W, Zhang Y et al., https://doi.org/10.4103/nrr.nrronline-d-26-00800, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"aging-longevity","name":"Biology of Aging & Longevity","domain_slug":"medicine"}],"cited_in_dossiers":[]}