{"id":"doi:10.5281/zenodo.22996625","kind":"article","title":"Bio-Synthetic Neuromorphic Interfacing: In Silico Integration of a Zero-Memory Fractal Decision Engine with the Whole-Brain Drosophila Melanogaster Connectome","authors":["Daghan Dagli","Volkan Dağlı"],"author_count":3,"year":2026,"published":"2026-09-27","venue":"Zenodo (CERN European Organization for Nuclear Research)","cited_by":1,"doi":"10.5281/zenodo.22996625","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.5281/zenodo.22996625","archive_url":"https://space-kitty.com/papers/doi:10.5281/zenodo.22996625","updated":null,"pmid":null,"pmcid":null,"openalex_id":"W7223743448","pdf_url":null,"abstract":"Interfacing artificial decision-making systems with biological neural substrates requires sub-millisecond response latency, zero memory overhead, and strict adherence to biophysical homeostasis. Here, we present the design, mathematical formulation, and in silico empirical validation of a bio-synthetic brain-machine interface coupling the complete 158,262-neuron, 3,990,039-synapse Drosophila melanogaster connectome (Princeton FlyWire) with an implantable 1,024-pin WERR neuromorphic fractal coprocessor. Rather than deploying parameterized tensor-based deep neural networks or spiking transformers that incur prohibitive memory-wall bottlenecks and 15–200 ms inference latencies, the coprocessor generates instantaneous System-1 reflex decisions by sampling chaotic Mandelbrot boundary escape trajectories (∂M), completely eliminating VRAM overhead (0 Bytes VRAM) and evaluating decisions in 0.461 ms. Four penetrating micro-electrode shanks target the Ellipsoid Body (EB) heading compass, the Descending Motor Neuron (DN) pool, and the bilateral Mushroom Bodies (MB). Official Patent Priority: TÜRKPATENT National Priority Application TR 2026/016633 (Priority Date: September 27, 2026, 06:16:04 UTC+3). All bio-synthetic neuromorphic coprocessor architectures, whole-brain connectome steering methods, and biophysical anti-burnout gating mechanisms are officially secured under the Paris Convention 12-month priority umbrella. Replication Package Contents: Complete open-source replication bundle (zenodo_bundle_werrsoma_drosophila_v1.0.zip) containing the CSR-compiled FlyWire 158k connectome cache, the 6-experiment empirical runner (run_scientific_experiments.py), raw benchmark telemetry (scientific_benchmark_results.json), the native Python 3D dual-viewport simulator (bioneural_fly_app.py), and the WebGL Three.js interactive visualizer (fly_bioneural_flight_sim.html).","abstract_license":"CC-BY (publisher license, via OpenAlex)","license":"cc-by","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Advanced Memory and Neural Computing"],"details":null,"provenance":"openalex","attribution":"Abstract of \"Bio-Synthetic Neuromorphic Interfacing: In Silico Integration of a Zero-Memory Fractal Decision Engine with the Whole-Brain Drosophila Melanogaster Connectome\" by Daghan Dagli, Volkan Dağlı, https://doi.org/10.5281/zenodo.22996625, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"connectomics","name":"Connectomics & Brain Mapping","domain_slug":"neuroscience"}],"cited_in_dossiers":[]}