{"id":"doi:10.7554/elife.18554","kind":"article","title":"High performance communication by people with paralysis using an intracortical brain-computer interface","authors":["Pandarinath C","Nuyujukian P","Blabe CH","Sorice BL","Saab J","Willett FR","Hochberg LR","Shenoy KV","Henderson JM"],"author_count":9,"year":2017,"published":"2017-02-21","venue":"eLife","cited_by":388,"doi":"10.7554/elife.18554","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.7554/elife.18554","archive_url":"https://space-kitty.com/papers/doi:10.7554/elife.18554","updated":null,"pmid":"28220753","pmcid":"PMC5319839","openalex_id":null,"pdf_url":"https://europepmc.org/articles/PMC5319839/pdf","abstract":"Brain-computer interfaces (BCIs) have the potential to restore communication for people with tetraplegia and anarthria by translating neural activity into control signals for assistive communication devices. While previous pre-clinical and clinical studies have demonstrated promising proofs-of-concept (Serruya et al., 2002; Simeral et al., 2011; Bacher et al., 2015; Nuyujukian et al., 2015; Aflalo et al., 2015; Gilja et al., 2015; Jarosiewicz et al., 2015; Wolpaw et al., 1998; Hwang et al., 2012; Spüler et al., 2012; Leuthardt et al., 2004; Taylor et al., 2002; Schalk et al., 2008; Moran, 2010; Brunner et al., 2011; Wang et al., 2013; Townsend and Platsko, 2016; Vansteensel et al., 2016; Nuyujukian et al., 2016; Carmena et al., 2003; Musallam et al., 2004; Santhanam et al., 2006; Hochberg et al., 2006; Ganguly et al., 2011; O'Doherty et al., 2011; Gilja et al., 2012), the performance of human clinical BCI systems is not yet high enough to support widespread adoption by people with physical limitations of speech. Here we report a high-performance intracortical BCI (iBCI) for communication, which was tested by three clinical trial participants with paralysis. The system leveraged advances in decoder design developed in prior pre-clinical and clinical studies (Gilja et al., 2015; Kao et al., 2016; Gilja et al., 2012). For all three participants, performance exceeded previous iBCIs (Bacher et al., 2015; Jarosiewicz et al., 2015) as measured by typing rate (by a factor of 1.4-4.2) and information throughput (by a factor of 2.2-4.0). This high level of performance demonstrates the potential utility of iBCIs as powerful assistive communication devices for people with limited motor function.Clinical Trial No: NCT00912041.","abstract_license":"CC0-1.0 (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)","license":"CC0-1.0","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":[],"details":null,"provenance":"europepmc","attribution":"Metadata: Europe PMC (EMBL-EBI).","topics":[{"slug":"brain-computer-interfaces","name":"Brain-Computer Interfaces","domain_slug":"neuroscience"}],"cited_in_dossiers":[]}