{"id":"doi:10.7759/cureus.51705","kind":"review","title":"Alzheimer’s Disease: The Past, Present, and Future of a Globally Progressive Disease","authors":["Bhuvanasai Vejandla","Sarah Savani","Rohith Appalaneni","Rithik S Veeravalli","Sai Sravya Gude"],"author_count":5,"year":2024,"published":"2024-01-05","venue":"Cureus","cited_by":43,"doi":"10.7759/cureus.51705","arxiv_id":null,"nct_id":null,"source_url":"https://doi.org/10.7759/cureus.51705","archive_url":"https://space-kitty.com/papers/doi:10.7759/cureus.51705","updated":null,"pmid":"38313929","pmcid":null,"openalex_id":"W4390618033","pdf_url":"https://assets.cureus.com/uploads/review_article/pdf/182967/20240105-3731-3mddw9.pdf","abstract":"Alzheimer's disease (AD) is a significant 21st-century public health challenge. This article delves into AD's neurodegenerative complexities, highlighting cognitive decline, memory impairment, and societal burdens. Mechanistically, protein misfolding, amyloid-beta (Aβ) pathway abnormalities, and genetic/environmental factors are discussed. The pivotal amyloid hypothesis is dissected, focusing on Aβ aggregation's role in synaptic dysfunction and neurodegeneration. The review showcases promising therapeutic strategies, including anti-amyloid antibodies and β/γ-secretase inhibitors targeting Aβ production. Notably, the FDA-approved Lecanemab signifies a breakthrough, slowing disease progression. Anti-Tau therapies' emergence is highlighted, addressing late-stage intervention. Tau aggregation blockers and anti-Tau antibodies offer potential against intracellular tau pathology. The review underscores collaborative efforts to uncover AD's secrets and pave the way for memory preservation.","abstract_license":"CC-BY (publisher license, via OpenAlex)","license":"cc-by","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Alzheimer's disease research and treatments"],"details":null,"provenance":"openalex","attribution":"Abstract of \"Alzheimer’s Disease: The Past, Present, and Future of a Globally Progressive Disease\" by Bhuvanasai Vejandla, Sarah Savani, Rohith Appalaneni et al., https://doi.org/10.7759/cureus.51705, used under its Creative Commons Attribution license (CC-BY); markup removed, otherwise unmodified.","topics":[{"slug":"neurodegeneration","name":"Alzheimer's, Parkinson's & Neurodegeneration","domain_slug":"medicine"}],"cited_in_dossiers":[]}