{"id":"nct:NCT00660894","kind":"trial","title":"Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery","authors":["Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan"],"author_count":1,"year":2008,"published":"2008-04-17","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT00660894","source_url":"https://clinicaltrials.gov/study/NCT00660894","archive_url":"https://space-kitty.com/papers/nct:NCT00660894","updated":"2016-08-03","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"RATIONALE: Drugs used in chemotherapy, such as tegafur-uracil, leucovorin, and S-1, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving tegafur-uracil together with leucovorin is more effective than giving S-1 in treating patients with stage III colon cancer. PURPOSE: This randomized phase III trial is studying giving tegafur-uracil together with leucovorin to see how well it works compared with giving S-1 in treating patients with stage III colon cancer that has been completely removed by surgery.","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Colorectal Cancer"],"details":{"acronym":null,"status":"COMPLETED","phase":"PHASE3","study_type":"INTERVENTIONAL","enrollment":1535,"sponsor":"Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan","conditions":["Colorectal Cancer"],"interventions":["DRUG: folinate calcium","DRUG: tegafur-uracil","DRUG: tegafur-gimeracil-oteracil potassium"],"start_date":"2008-04-01","start_date_type":null,"primary_completion_date":"2012-06-01","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"gene-cell-therapy","name":"Gene & Cell Therapy","domain_slug":"medicine"}],"cited_in_dossiers":[]}