{"id":"nct:NCT00975897","kind":"trial","title":"Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer","authors":["Medical Research Council"],"author_count":1,"year":2009,"published":"2009-09-14","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT00975897","source_url":"https://clinicaltrials.gov/study/NCT00975897","archive_url":"https://space-kitty.com/papers/nct:NCT00975897","updated":"2013-12-19","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors select the best treatment for patients and predict their response to treatment. PURPOSE: This randomized phase II/III trial is studying how well tumor tissue testing works in selecting treatment for patients with metastatic or locally advanced colorectal cancer.","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Colorectal Cancer"],"details":{"acronym":null,"status":"COMPLETED","phase":"PHASE2, PHASE3","study_type":"INTERVENTIONAL","enrollment":3240,"sponsor":"Medical Research Council","conditions":["Colorectal Cancer"],"interventions":["BIOLOGICAL: bevacizumab","BIOLOGICAL: cetuximab","DRUG: fluorouracil","DRUG: irinotecan hydrochloride","DRUG: leucovorin calcium","DRUG: oxaliplatin","GENETIC: RNA analysis","GENETIC: cytogenetic analysis","GENETIC: fluorescence in situ hybridization","GENETIC: gene expression analysis"],"start_date":"2009-07-01","start_date_type":null,"primary_completion_date":"2010-08-01","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"gene-cell-therapy","name":"Gene & Cell Therapy","domain_slug":"medicine"}],"cited_in_dossiers":[]}