{"id":"nct:NCT02497287","kind":"trial","title":"A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression","authors":["Janssen Research & Development, LLC"],"author_count":1,"year":2015,"published":"2015-07-14","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT02497287","source_url":"https://clinicaltrials.gov/study/NCT02497287","archive_url":"https://space-kitty.com/papers/nct:NCT02497287","updated":"2025-04-29","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"The purpose of this open-label, multicenter study is to assess the long term safety and efficacy of intranasal esketamine plus an oral antidepressant in participants with treatment-resistant depression (TRD).","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"peer_reviewed":null,"categories":["Treatment-resistant Depression"],"details":{"acronym":"SUSTAIN-2","status":"COMPLETED","phase":"PHASE3","study_type":"INTERVENTIONAL","enrollment":802,"sponsor":"Janssen Research & Development, LLC","conditions":["Treatment-resistant Depression"],"interventions":["DRUG: Esketamine (Intranasal Spray)","DRUG: Duloxetine (Oral Antidepressant)","DRUG: Escitalopram (Oral Antidepressant)","DRUG: Sertraline (Oral Antidepressant)","DRUG: Venlafaxine Extended Release (XR) (Oral Antidepressant)"],"start_date":"2015-09-30","start_date_type":"ACTUAL","primary_completion_date":"2017-10-28","has_results":true,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"psychiatric-therapeutics","name":"Novel Psychiatric Therapeutics","domain_slug":"neuroscience"}],"cited_in_dossiers":[]}