{"id":"nct:NCT04102371","kind":"trial","title":"Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis","authors":["Children's Hospital of Philadelphia"],"author_count":1,"year":2019,"published":"2019-09-25","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT04102371","source_url":"https://clinicaltrials.gov/study/NCT04102371","archive_url":"https://space-kitty.com/papers/nct:NCT04102371","updated":"2026-03-05","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% \"normal\" saline in children with septic shock, including whether balanced fluid resuscitation can reduce progression of kidney injury.","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Shock","Septic"],"details":{"acronym":"PRoMPT BOLUS","status":"COMPLETED","phase":"PHASE3","study_type":"INTERVENTIONAL","enrollment":9041,"sponsor":"Children's Hospital of Philadelphia","conditions":["Shock","Septic"],"interventions":["DRUG: Lactated Ringer","DRUG: Normal Saline","DRUG: Plasma-lyte"],"start_date":"2020-08-25","start_date_type":"ACTUAL","primary_completion_date":"2025-12-01","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"infectious-disease-amr","name":"Infectious Disease, Vaccines & Antimicrobial Resistance","domain_slug":"medicine"}],"cited_in_dossiers":[]}