{"id":"nct:NCT04425473","kind":"trial","title":"Esketamine and Perioperative Depressive Symptoms","authors":["Beijing Tiantan Hospital"],"author_count":1,"year":2020,"published":"2020-06-11","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT04425473","source_url":"https://clinicaltrials.gov/study/NCT04425473","archive_url":"https://space-kitty.com/papers/nct:NCT04425473","updated":"2025-08-01","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"Perioperative depressive symptoms (PDS) are common in population undergoing surgery, and this would be sharpened especially for complicated, high-risk major surgery. However, None of treatments could resolve this clinical problem during limited perioperative period. The remarkable effects of ketamine on treatment resistant depression have been verified by several clinical trials and the enantiomer S-ketamine (esketamine) showed similar antidepressant efficacy with better safety in recent studies. The efficacy and safety of esketamine administrated intra-operatively for PDS will be verified in this study. Other secondary outcomes such as anxiety, postoperative pain and psychiatric symptoms will also be investigated.","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"peer_reviewed":null,"categories":["Depressive Symptoms","Esketamine","Perioperative Complication","Major Surgery"],"details":{"acronym":null,"status":"COMPLETED","phase":"PHASE2, PHASE3","study_type":"INTERVENTIONAL","enrollment":435,"sponsor":"Beijing Tiantan Hospital","conditions":["Depressive Symptoms","Esketamine","Perioperative Complication","Major Surgery"],"interventions":["DRUG: Esketamine","DRUG: Normal saline"],"start_date":"2021-02-19","start_date_type":"ACTUAL","primary_completion_date":"2024-06-23","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"psychiatric-therapeutics","name":"Novel Psychiatric Therapeutics","domain_slug":"neuroscience"}],"cited_in_dossiers":[]}