{"id":"nct:NCT07104916","kind":"trial","title":"Mindfulness-based Psilocybin Therapy for PTSD","authors":["Anthony P King"],"author_count":1,"year":2025,"published":"2025-08-05","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT07104916","source_url":"https://clinicaltrials.gov/study/NCT07104916","archive_url":"https://space-kitty.com/papers/nct:NCT07104916","updated":"2026-10-19","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD). This is an assessor-blinded, randomized, controlled study in participants with PTSD. The study will investigate the changes in brain activity, connectivity, and microstructural neuroplasticity assessed using EEG/EMG and multimodal MRI measures after administration of one oral dose of psilocybin, accompanied either with standard \"psychological support\" only; or with standard support plus Mindfulness-based Cognitive Therapy (MBCT).","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Post Traumatic Stress Disorder","Depression - Major Depressive Disorder"],"details":{"acronym":null,"status":"RECRUITING","phase":"PHASE2","study_type":"INTERVENTIONAL","enrollment":30,"sponsor":"Anthony P King","conditions":["Post Traumatic Stress Disorder","Depression - Major Depressive Disorder"],"interventions":["COMBINATION_PRODUCT: Psilocybin + MBCT therapy","COMBINATION_PRODUCT: Active Comparator: Psilocybin with Support Only"],"start_date":"2026-09-01","start_date_type":"ACTUAL","primary_completion_date":"2029-09-01","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"psychiatric-therapeutics","name":"Novel Psychiatric Therapeutics","domain_slug":"neuroscience"}],"cited_in_dossiers":[]}