{"id":"nct:NCT07293260","kind":"trial","title":"Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial","authors":["Amgen"],"author_count":1,"year":2025,"published":"2025-12-19","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT07293260","source_url":"https://clinicaltrials.gov/study/NCT07293260","archive_url":"https://space-kitty.com/papers/nct:NCT07293260","updated":"2026-04-16","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"The primary objective of this trial is to evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA).","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Cardiovascular Disease"],"details":{"acronym":"OCEAN(a)-CCTA","status":"RECRUITING","phase":"PHASE3","study_type":"INTERVENTIONAL","enrollment":406,"sponsor":"Amgen","conditions":["Cardiovascular Disease"],"interventions":["DRUG: Olpasiran","DRUG: Placebo"],"start_date":"2026-03-23","start_date_type":"ACTUAL","primary_completion_date":"2028-06-15","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"cardiovascular-innovation","name":"Cardiovascular Therapeutics","domain_slug":"medicine"}],"cited_in_dossiers":[]}