{"id":"nct:NCT07549698","kind":"trial","title":"Safety and Preliminary Efficacy of CTX112 in Adult Participants With Relapsed/Refractory Hematologic Autoimmune Disease","authors":["CRISPR Therapeutics AG"],"author_count":1,"year":2026,"published":"2026-04-24","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT07549698","source_url":"https://clinicaltrials.gov/study/NCT07549698","archive_url":"https://space-kitty.com/papers/nct:NCT07549698","updated":"2026-10-20","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"This is a single-arm, open-label, multicenter, ascending dose Phase 1/2 trial evaluating the safety and preliminary efficacy of CTX112 or Zugocabtagene geleucel (zugo-cel) in adult participants with relapsed/refractory primary Immune Thrombocytopenia (ITP) and relapsed/refractory primary Warm Autoimmune Hemolytic Anemia (wAIHA).","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"peer_reviewed":null,"categories":["Warm Autoimmune Hemolytic Anemia (WAIHA)","ITP - Immune Thrombocytopenia","Warm Autoimmune Hemolytic Anemia","Immune Thrombocytopenic Purpura"],"details":{"acronym":null,"status":"RECRUITING","phase":"PHASE1, PHASE2","study_type":"INTERVENTIONAL","enrollment":60,"sponsor":"CRISPR Therapeutics AG","conditions":["Warm Autoimmune Hemolytic Anemia (WAIHA)","ITP - Immune Thrombocytopenia","Warm Autoimmune Hemolytic Anemia","Immune Thrombocytopenic Purpura"],"interventions":["BIOLOGICAL: CTX112"],"start_date":"2026-07-17","start_date_type":"ACTUAL","primary_completion_date":"2033-12-01","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"gene-editing-therapies","name":"CRISPR & Gene-Editing Therapies","domain_slug":"medicine"}],"cited_in_dossiers":[]}