{"id":"nct:NCT07614958","kind":"trial","title":"Phase 3 Clinical Study Evaluating Efficacy, Safety, and Tolerability of Obicetrapib Vs Bempedoic Acid to Treat Dyslipidemia in Adults With Primary Non-familial Hypercholesterolemia or Mixed Dyslipidemia at High to Very High Cardiovascular Risk, During a Treatment Period of Approximately 84 Days","authors":["A. Menarini International Licensing S.A."],"author_count":1,"year":2026,"published":"2026-05-29","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT07614958","source_url":"https://clinicaltrials.gov/study/NCT07614958","archive_url":"https://space-kitty.com/papers/nct:NCT07614958","updated":"2026-06-09","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"This Phase 3, randomized, double-blind, active-controlled study evaluates the efficacy and safety of obicetrapib (OBI) compared to bempedoic acid (BPA) in participants with dyslipidemia at high or very high cardiovascular risk. Participants must have elevated low density lipoprotein cholesterol (LDL-C) levels despite receiving maximally tolerated lipid lowering therapy. The primary objective is to compare the LDL-C lowering effect of OBI (a CETP inhibitor) against BPA at 12 weeks","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Mixed Dyslipidemia","Hypercholesterolaemia"],"details":{"acronym":"MEDICI","status":"RECRUITING","phase":"PHASE3","study_type":"INTERVENTIONAL","enrollment":426,"sponsor":"A. Menarini International Licensing S.A.","conditions":["Mixed Dyslipidemia","Hypercholesterolaemia"],"interventions":["DRUG: Obicetrapib 10 mg/Bempedoic Acid Placebo","DRUG: Bempedoic Acid 180mg/Placebo Obicetrapib"],"start_date":"2026-05-06","start_date_type":"ACTUAL","primary_completion_date":"2027-01-01","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"cardiovascular-innovation","name":"Cardiovascular Therapeutics","domain_slug":"medicine"}],"cited_in_dossiers":[]}