{"id":"nct:NCT07709741","kind":"trial","title":"Sustained Release Oral Formulation For Treatment Of Parkinsons Disease","authors":["University of Minnesota"],"author_count":1,"year":2026,"published":"2026-07-16","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT07709741","source_url":"https://clinicaltrials.gov/study/NCT07709741","archive_url":"https://space-kitty.com/papers/nct:NCT07709741","updated":"2026-10-01","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"LD/CD (medications to treat Parkinson's disease) will be delivered using an assembly of nested sachets made of permeable material. The assembly is placed in the oral/buccal cavity (between cheek and gum of lower jaw) and delivers continuous release of CD and LD for both transmucosal and gastrointestinal absorption. The combination of CD/LD in the inner sachet varies from that in the outer sachet. This allows for sequential release of CD and then LD to mimic a CD pretreatment method which is known to increase LD absorption and prolong its half-life.","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Healthy Volunteers"],"details":{"acronym":null,"status":"NOT_YET_RECRUITING","phase":"PHASE1, PHASE2","study_type":"INTERVENTIONAL","enrollment":32,"sponsor":"University of Minnesota","conditions":["Healthy Volunteers"],"interventions":["DRUG: Formulation A","DRUG: Formulation B","DRUG: Formulation C"],"start_date":"2027-04-01","start_date_type":"ESTIMATED","primary_completion_date":"2027-06-30","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"neurodegeneration","name":"Alzheimer's, Parkinson's & Neurodegeneration","domain_slug":"medicine"}],"cited_in_dossiers":[]}