{"id":"nct:NCT07745790","kind":"trial","title":"Safety and Efficacy of Multimodal Thermal Therapy (MTT) Combined With KRAS G12V mRNA Vaccine, S-1, and Sintilimab in Patients With Metastatic Pancreatic Cancer","authors":["Ruijin Hospital"],"author_count":1,"year":2026,"published":"2026-08-04","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT07745790","source_url":"https://clinicaltrials.gov/study/NCT07745790","archive_url":"https://space-kitty.com/papers/nct:NCT07745790","updated":"2026-08-04","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"This is a single-arm, single-center, exploratory clinical study. A total of 20 participants with metastatic pancreatic ductal adenocarcinoma (with liver or lung metastasis) who have experienced disease progression after or are intolerant to standard first-line chemotherapy (based on the AG regimen \\[Albumin-bound Paclitaxel plus Gemcitabine\\]) will be enrolled.The study aims to evaluate the safety, efficacy, and underlying immunological mechanisms of Multimodal Thermal Therapy (MTT) combined with a KRAS G12V mRNA vaccine, S-1, and Sintilimab.","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Pancreatic Ductal Adenocarcinoma","Liver Neoplasms","Lung Neoplasms"],"details":{"acronym":null,"status":"NOT_YET_RECRUITING","phase":"PHASE2","study_type":"INTERVENTIONAL","enrollment":20,"sponsor":"Ruijin Hospital","conditions":["Pancreatic Ductal Adenocarcinoma","Liver Neoplasms","Lung Neoplasms"],"interventions":["DEVICE: Multimodal Thermal Therapy (MTT) System","BIOLOGICAL: KRAS G12V mRNA Vaccine","DRUG: Sintilimab","DRUG: S-1"],"start_date":"2026-07-13","start_date_type":"ESTIMATED","primary_completion_date":"2029-07-31","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"mrna-cancer-vaccines","name":"mRNA Therapeutics & Cancer Vaccines","domain_slug":"medicine"}],"cited_in_dossiers":[]}