{"id":"nct:NCT07804004","kind":"trial","title":"A Safety and Efficacy Study Evaluating CTX112 in Subjects With Refractory Neurologic Autoimmune Disease","authors":["CRISPR Therapeutics"],"author_count":1,"year":2026,"published":"2026-09-04","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT07804004","source_url":"https://clinicaltrials.gov/study/NCT07804004","archive_url":"https://space-kitty.com/papers/nct:NCT07804004","updated":"2026-10-22","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"This is a single-arm, open-label, multicenter, ascending dose Phase 1/2 trial evaluating the safety and preliminary efficacy of CTX112 in adult participants with neurological autoimmune diseases (AIDs), including Progressive Multiple Sclerosis, relapsing Neuromyelitis Optica Spectrum Disorder, relapsing Myelin Oligodendrocyte Glycoprotein Antiody-Associated Disease, refractory AutoImmune Encephalitis, and refractory Stiff Person Syndrome","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Progressive Multiple Sclerosis (PMS)","Neuromyelitis Optica","Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease","Autoimmune Encephalitis","Stiff-Person Syndrome"],"details":{"acronym":"CRSP-AID-502","status":"NOT_YET_RECRUITING","phase":"PHASE1, PHASE2","study_type":"INTERVENTIONAL","enrollment":220,"sponsor":"CRISPR Therapeutics","conditions":["Progressive Multiple Sclerosis (PMS)","Neuromyelitis Optica","Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease","Autoimmune Encephalitis","Stiff-Person Syndrome"],"interventions":["BIOLOGICAL: CTX112"],"start_date":"2026-11-01","start_date_type":"ESTIMATED","primary_completion_date":"2029-12-30","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"gene-editing-therapies","name":"CRISPR & Gene-Editing Therapies","domain_slug":"medicine"}],"cited_in_dossiers":[]}