{"id":"nct:NCT07831577","kind":"trial","title":"Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis","authors":["Genascence Corporation"],"author_count":1,"year":2026,"published":"2026-09-21","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT07831577","source_url":"https://clinicaltrials.gov/study/NCT07831577","archive_url":"https://space-kitty.com/papers/nct:NCT07831577","updated":"2026-09-21","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"The goal of this clinical trial is to learn if GNSC-001 works to treat knee osteoarthritis in adults. It will also learn about the safety of GNSC-001. The main questions it aims to answer are: 1. Does GNSC-001 lower daily knee joint pain and improve function in participants? 2. What medical problems do participants have when taking GNSC-001? Researchers will compare GNSC-001 to a placebo (a look-alike substance that contains no drug) to see if GNSC-001 works to treat knee osteoarthritis. Participants will: 1. Receive a single injection of immune-modulation, and GNSC-001 or a placebo, in their knee 2. Take an oral immune-modulating pill every day for the first 22 days 3. Visit the clinic at least 9 times over 2 years for checkups and tests 4. Keep a diary of their symptoms and the number of times they use a rescue medication","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Knee Arthritis Osteoarthritis","Knee Arthritis, Osteoarthritis","Knee Arthritis","Knee Arthritis Disease","Osteo Arthritis of the Knee","Osteoarthritic Knee Pain"],"details":{"acronym":"RAPHAEL","status":"NOT_YET_RECRUITING","phase":"PHASE2, PHASE3","study_type":"INTERVENTIONAL","enrollment":240,"sponsor":"Genascence Corporation","conditions":["Knee Arthritis Osteoarthritis","Knee Arthritis, Osteoarthritis","Knee Arthritis","Knee Arthritis Disease","Osteo Arthritis of the Knee","Osteoarthritic Knee Pain","Osteoarthritis (OA) of the Knee","Osteo Arthritis Knee","Pain (Knee)"],"interventions":["DRUG: Gene Therapy GNSC-001","DRUG: Placebo"],"start_date":"2027-07-01","start_date_type":"ESTIMATED","primary_completion_date":"2029-10-01","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"gene-cell-therapy","name":"Gene & Cell Therapy","domain_slug":"medicine"}],"cited_in_dossiers":[]}