{"id":"nct:NCT07839936","kind":"trial","title":"A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular Disease","authors":["Verve Therapeutics, Inc."],"author_count":1,"year":2026,"published":"2026-09-24","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT07839936","source_url":"https://clinicaltrials.gov/study/NCT07839936","archive_url":"https://space-kitty.com/papers/nct:NCT07839936","updated":"2026-09-24","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"The purpose of this study is to measure the change in bad cholesterol (LDL-C) with VERVE-102 compared to placebo in adults who have plaque buildup in their arteries or are at high risk of developing it.","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"peer_reviewed":null,"categories":["Atherosclerosis","Cardiovascular Disease","Hypercholesterolemia"],"details":{"acronym":"HEART-3","status":"NOT_YET_RECRUITING","phase":"PHASE2","study_type":"INTERVENTIONAL","enrollment":175,"sponsor":"Verve Therapeutics, Inc.","conditions":["Atherosclerosis","Cardiovascular Disease","Hypercholesterolemia"],"interventions":["DRUG: VERVE-102","DRUG: Placebo"],"start_date":"2026-10-01","start_date_type":"ESTIMATED","primary_completion_date":"2028-08-01","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"gene-editing-therapies","name":"CRISPR & Gene-Editing Therapies","domain_slug":"medicine"}],"cited_in_dossiers":[]}