{"id":"nct:NCT07858916","kind":"trial","title":"A Phase 2b Study to Evaluate the Efficacy, Safety, and PK Profiles of TNP-2092 Administered Via IA Injection in PJI Participants","authors":["TenNor Therapeutics (Zhongshan) Limited"],"author_count":1,"year":2026,"published":"2026-10-05","venue":"ClinicalTrials.gov","cited_by":null,"doi":null,"arxiv_id":null,"nct_id":"NCT07858916","source_url":"https://clinicaltrials.gov/study/NCT07858916","archive_url":"https://space-kitty.com/papers/nct:NCT07858916","updated":"2026-10-28","pmid":null,"pmcid":null,"openalex_id":null,"pdf_url":null,"abstract":"This is a Phase 2b, randomized, controlled, open-label clinical study evaluating the efficacy, safety, and local PK profiles of TNP-2092 administered via IA injection on a background of antibiotic treatment in participants with early postoperative (within 3 months after index arthroplasty) or acute hematogenous (within 4 weeks of infection) PJI after knee arthroplasty, without debridement, and in participants with chronic PJI (including PJI occurring after various joint arthroplasties and revision arthroplasties) requiring long-term antibiotic suppressive treatment.","abstract_license":"ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters","license":"ClinicalTrials.gov terms (attribution, processing date, modifications noted)","is_open_access":true,"retracted":false,"peer_reviewed":null,"categories":["Prosthetic Joint Infection (PJI)"],"details":{"acronym":null,"status":"RECRUITING","phase":"PHASE2","study_type":"INTERVENTIONAL","enrollment":40,"sponsor":"TenNor Therapeutics (Zhongshan) Limited","conditions":["Prosthetic Joint Infection (PJI)"],"interventions":["DRUG: TNP-2092 for injection","DRUG: Vancomycin Hydrochloride for Injection","DRUG: Oral antibiotics","DRUG: Appropriate intravenous and/or oral antibiotics"],"start_date":"2026-10-21","start_date_type":"ACTUAL","primary_completion_date":"2027-09-01","has_results":false,"data_source":"ClinicalTrials.gov","data_processed":"2026-10-29T09:00:05","modifications":"selected fields only; whitespace normalized; brief summary truncated to 2,000 characters"},"provenance":"clinicaltrials","attribution":"Source: ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters. Not a U.S. Government endorsement.","topics":[{"slug":"infectious-disease-amr","name":"Infectious Disease, Vaccines & Antimicrobial Resistance","domain_slug":"medicine"}],"cited_in_dossiers":[]}