# Topological Quantum Biomaterials Enable Pyroptosis-Senescence Coupling for Enhanced Colorectal Cancer Therapy

Article · Chen Z, Mei K, Yang Y, Xu M, Dai X, Gu R, Zhou F, Wang C, Chang M, Huang Y, Chen Y

- Archive id: doi:10.1002/advs.77968
- Published: 2026-09-30
- Venue: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
- DOI: https://doi.org/10.1002/advs.77968
- PMID: 42814474
- PMCID: PMC13626165
- Citations: 0
- Source URL: https://doi.org/10.1002/advs.77968
- PDF: https://europepmc.org/articles/PMC13626165/pdf
- Provenance: europepmc

## Abstract

Inducing pyroptosis in tumor cells has emerged as a promising anticancer strategy. However, under sublethal oxidative stress, a considerable fraction of cancer cells evades pyroptosis and undergoes therapy-induced senescence, which ultimately drives chronic inflammation and facilitates tumor relapse. Here, we report an ultrasound-responsive sequential therapeutic strategy that orchestrates the pyroptosis-senescence axis for improved colorectal cancer therapy. This sequential therapeutic strategy integrates two functional modules, including morphologically engineered Pd 3 Sn topological quantum biomaterials and senolytic agent piperlongumine. Upon ultrasound irradiation, the tailored Pd 3 Sn nanostructures generate reactive oxygen species, which subsequently trigger zDHHC5-mediated S-acylation of gasdermin D, thereby initiating pyroptosis in colorectal cancer cells. Benefiting from its facet dependent near Fermi level electronic states and favorable peroxide activation kinetics, Pd 3 Sn achieves substantially improved sonocatalytic performance, allowing for the controlled production of radicals and the accurate triggering of the pyroptosis cascade. Intriguingly, the senescence-associated secretory phenotype factors released from pyroptotic cells drive the surviving cancer cells into a senescent state. These senescent cells are then selectively eliminated by piperlongumine, effectively abrogating their senescence-associated pro-tumorigenic effects. In subcutaneous and liver metastasis models, this nanoplatform significantly suppresses tumor progression, achieving an 83.4% tumor volume inhibition rate and minimal liver metastatic burden. This work opens the application of quantum biomaterials in biomedicine and establishes a new therapeutic paradigm for disease treatment.

_Abstract reproduced under CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)._

Topics: [Biology of Aging & Longevity](https://space-kitty.com/topics/aging-longevity)

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