# Past, present, and future of CRISPR genome editing technologies

Review · Martin Pačesa, Oana Pelea, Martin Jínek

- Archive id: doi:10.1016/j.cell.2024.01.042
- Published: 2024-02-01
- Venue: Cell
- DOI: https://doi.org/10.1016/j.cell.2024.01.042
- PMID: 38428389
- Citations: 607
- Source URL: https://doi.org/10.1016/j.cell.2024.01.042
- Provenance: openalex

## Abstract

Genome editing has been a transformative force in the life sciences and human medicine, offering unprecedented opportunities to dissect complex biological processes and treat the underlying causes of many genetic diseases. CRISPR-based technologies, with their remarkable efficiency and easy programmability, stand at the forefront of this revolution. In this Review, we discuss the current state of CRISPR gene editing technologies in both research and therapy, highlighting limitations that constrain them and the technological innovations that have been developed in recent years to address them. Additionally, we examine and summarize the current landscape of gene editing applications in the context of human health and therapeutics. Finally, we outline potential future developments that could shape gene editing technologies and their applications in the coming years.

_Abstract reproduced under CC-BY (publisher license, via OpenAlex)._

Topics: [CRISPR & Gene-Editing Therapies](https://space-kitty.com/topics/gene-editing-therapies)

---
Space Kitty Archive · https://space-kitty.com · API: https://space-kitty.com/api/v1 · MCP: https://space-kitty.com/mcp · Premium: $0.20/request via x402 (Base Sepolia (testnet)). Metadata: arXiv (CC0), OpenAlex (CC0), Europe PMC (CC BY/CC0 works), ClinicalTrials.gov.