# The AlphaFold Database of Protein Structures: A Biologist's Guide

Review · David A, Islam S, Tankhilevich E, Sternberg MJE

- Archive id: doi:10.1016/j.jmb.2021.167336
- Published: 2021-10-29
- Venue: Journal of molecular biology
- DOI: https://doi.org/10.1016/j.jmb.2021.167336
- PMID: 34757056
- PMCID: PMC8783046
- Citations: 193
- Source URL: https://doi.org/10.1016/j.jmb.2021.167336
- PDF: https://europepmc.org/articles/PMC8783046/pdf
- Provenance: europepmc

## Abstract

AlphaFold, the deep learning algorithm developed by DeepMind, recently released the three-dimensional models of the whole human proteome to the scientific community. Here we discuss the advantages, limitations and the still unsolved challenges of the AlphaFold models from the perspective of a biologist, who may not be an expert in structural biology.

_Abstract reproduced under CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)._

Topics: [AI Protein Design & Structure Prediction](https://space-kitty.com/topics/protein-design)

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