# The dysconnection hypothesis (2016)

Review · Friston K, Brown HR, Siemerkus J, Stephan KE

- Archive id: doi:10.1016/j.schres.2016.07.014
- Published: 2016-07-20
- Venue: Schizophrenia research
- DOI: https://doi.org/10.1016/j.schres.2016.07.014
- PMID: 27450778
- PMCID: PMC5147460
- Citations: 476
- Source URL: https://doi.org/10.1016/j.schres.2016.07.014
- PDF: https://europepmc.org/articles/PMC5147460/pdf
- Provenance: europepmc

## Abstract

Twenty years have passed since the dysconnection hypothesis was first proposed (Friston and Frith, 1995; Weinberger, 1993). In that time, neuroscience has witnessed tremendous advances: we now live in a world of non-invasive neuroanatomy, computational neuroimaging and the Bayesian brain. The genomics era has come and gone. Connectomics and large-scale neuroinformatics initiatives are emerging everywhere. So where is the dysconnection hypothesis now? This article considers how the notion of schizophrenia as a dysconnection syndrome has developed - and how it has been enriched by recent advances in clinical neuroscience. In particular, we examine the dysconnection hypothesis in the context of (i) theoretical neurobiology and computational psychiatry; (ii) the empirical insights afforded by neuroimaging and associated connectomics - and (iii) how bottom-up (molecular biology and genetics) and top-down (systems biology) perspectives are converging on the mechanisms and nature of dysconnections in schizophrenia.

_Abstract reproduced under CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)._

Topics: [Connectomics & Brain Mapping](https://space-kitty.com/topics/connectomics)

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