# Targeting grasp-related cortical areas for intracortical brain-machine interfaces

Article · Johnson TR, Foli C, Conlan EC, Koenig KA, Lowe MJ, Memberg WD, Kirsch RF, Herring EZ, Bazarek SF, Graczyk EL, Taylor DM, Bolu Ajiboye A, Sweet JA

- Archive id: doi:10.1016/j.ynirp.2026.100381
- Published: 2026-07-10
- Venue: Neuroimage. Reports
- DOI: https://doi.org/10.1016/j.ynirp.2026.100381
- PMID: 42473457
- PMCID: PMC13380800
- Citations: 1
- Source URL: https://doi.org/10.1016/j.ynirp.2026.100381
- PDF: https://europepmc.org/articles/PMC13380800/pdf
- Provenance: europepmc

## Abstract

This study aimed to improve intracortical microelectrode array implantation sites for grasp-related motor decoding by integrating anatomical, functional, and vascular imaging with preoperative 3D modeling. A participant with C5 tetraplegia underwent anatomical MRI, diffusion-weighted imaging, and task-based fMRI to identify grasp-related cortical regions while avoiding vasculature and speech-critical areas. Quicktome software was used to refine target selection by integrating structural connectivity and functional activation data. A 3D-printed skull and cortical model enabled preoperative planning, including craniotomy and electrode positioning simulations. Electrode placement was validated postoperatively using neural data collected from the implanted arrays during attempted movements of the arm and hand. Functional imaging identified distinct grasp-related activation in anterior intraparietal area (AIP), ventral premotor cortex (PMv), and inferior frontal gyrus (IFG). Putative AIP was selected based on its strong connectivity with motor cortex and distinct functional activation. Subregions 6v and 6r of PMv, which exhibited robust grasp-related activity and were surgically accessible, were chosen over the posterior IFG region, which extended into a sulcus making implantation difficult. Postoperatively, the arrays enabled high-fidelity decoding of arm/hand movements, achieving a combined classification accuracy of 96%. This study presents a multi-modal approach for improving intracortical electrode placement by combining MRI-based anatomical mapping, fMRI-guided functional localization, connectivity information, and 3D surgical modeling. These findings demonstrate an effective method for identifying surgically feasible grasp network implant locations in a paralyzed individual. This is an essential step toward brain-machine interfaces that enable individuals with spinal cord injury to control devices using grasp-related brain activity.

_Abstract reproduced under CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)._

Topics: [Brain-Computer Interfaces](https://space-kitty.com/topics/brain-computer-interfaces)

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