# Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

Article · Jinfang Zhang, Xia Bu, Haizhen Wang, Yasheng Zhu, Yan Geng, Naoe Taira Nihira, Yuyong Tan, Yanpeng Ci, Fei Wu, Xiangpeng Dai, Jianping Guo, Yuhan Huang, Caoqi Fan, Shancheng Ren, Yinghao Sun, Gordon James Freeman, Piotr Siciński, Wenyi Wei

- Archive id: doi:10.1038/nature25015
- Published: 2017-11-16
- Venue: Nature
- DOI: https://doi.org/10.1038/nature25015
- PMID: 29160310
- Citations: 1,013
- Source URL: https://doi.org/10.1038/nature25015
- Provenance: openalex

_Abstract not reproduced: its license does not permit redistribution. See the source URL._

Topics: [Cancer Immunotherapy](https://space-kitty.com/topics/cancer-immunotherapy)

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