# Customizing cellular signal processing by synthetic multi-level regulatory circuits

Review · Gao Y, Wang L, Wang B

- Archive id: doi:10.1038/s41467-023-44256-1
- Published: 2023-12-18
- Venue: Nature communications
- DOI: https://doi.org/10.1038/s41467-023-44256-1
- PMID: 38110405
- PMCID: PMC10728147
- Citations: 57
- Source URL: https://doi.org/10.1038/s41467-023-44256-1
- PDF: https://europepmc.org/articles/PMC10728147/pdf
- Provenance: europepmc

## Abstract

As synthetic biology permeates society, the signal processing circuits in engineered living systems must be customized to meet practical demands. Towards this mission, novel regulatory mechanisms and genetic circuits with unprecedented complexity have been implemented over the past decade. These regulatory mechanisms, such as transcription and translation control, could be integrated into hybrid circuits termed "multi-level circuits". The multi-level circuit design will tremendously benefit the current genetic circuit design paradigm, from modifying basic circuit dynamics to facilitating real-world applications, unleashing our capabilities to customize cellular signal processing and address global challenges through synthetic biology.

_Abstract reproduced under CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)._

Topics: [Synthetic Biology & Genome Engineering](https://space-kitty.com/topics/synthetic-biology)

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