# Advances in the development and delivery of nucleic acid-based therapeutics

Review · Kurczewski E, Mansurov A, Sachar C, Guler MO

- Archive id: doi:10.1039/d6bm00738d
- Published: 2026-09-29
- Venue: Biomaterials science
- DOI: https://doi.org/10.1039/d6bm00738d
- PMID: 42644266
- Citations: 0
- Source URL: https://doi.org/10.1039/d6bm00738d
- Provenance: europepmc

## Abstract

Recent advancements in experimental and computational methods along with growing gene sequencing libraries have enabled rapid development of nucleic acid-based therapeutic design for a wide variety of diseases. New drugs, delivery tools and methods have enabled precise and efficient therapy at a molecular scale. This review covers the current landscape and future directions of methods for gene and cell therapies, as well as their applications, advantages, and limitations. We present self-amplifying RNA, circular RNA, CRISPR systems, antisense oligonucleotides, and antibody-oligonucleotide conjugates, as well as CAR modification of T-cells, natural killer cells, and macrophages, with a brief discussion of modified stem cells. We also discuss developments in viral and non-viral delivery systems for their applications in cell and gene therapies.

_Abstract reproduced under CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)._

Topics: [mRNA Therapeutics & Cancer Vaccines](https://space-kitty.com/topics/mrna-cancer-vaccines)

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