# AlphaPulldown-a python package for protein-protein interaction screens using AlphaFold-Multimer

Article · Yu D, Chojnowski G, Rosenthal M, Kosinski J

- Archive id: doi:10.1093/bioinformatics/btac749
- Published: 2023-01-01
- Venue: Bioinformatics (Oxford, England)
- DOI: https://doi.org/10.1093/bioinformatics/btac749
- PMID: 36413069
- PMCID: PMC9805587
- Citations: 177
- Source URL: https://doi.org/10.1093/bioinformatics/btac749
- PDF: https://europepmc.org/articles/PMC9805587/pdf
- Provenance: europepmc

## Abstract

Summary The artificial intelligence-based structure prediction program AlphaFold-Multimer enabled structural modelling of protein complexes with unprecedented accuracy. Increasingly, AlphaFold-Multimer is also used to discover new protein-protein interactions (PPIs). Here, we present AlphaPulldown, a Python package that streamlines PPI screens and high-throughput modelling of higher-order oligomers using AlphaFold-Multimer. It provides a convenient command-line interface, a variety of confidence scores and a graphical analysis tool. Availability and implementation AlphaPulldown is freely available at https://www.embl-hamburg.de/AlphaPulldown. Supplementary information Supplementary note is available at Bioinformatics online.

_Abstract reproduced under CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)._

Topics: [AI Protein Design & Structure Prediction](https://space-kitty.com/topics/protein-design)

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