# Various AAV Serotypes and Their Applications in Gene Therapy: An Overview

Review · Shaza S. Issa, Alisa A. Shaimardanova, Valeriya V. Solovyeva, Albert Anatolyevich Rizvanov

- Archive id: doi:10.3390/cells12050785
- Published: 2023-03-01
- Venue: Cells
- DOI: https://doi.org/10.3390/cells12050785
- PMID: 36899921
- Citations: 313
- Source URL: https://doi.org/10.3390/cells12050785
- PDF: https://www.mdpi.com/2073-4409/12/5/785/pdf?version=1677688095
- Provenance: openalex

## Abstract

Despite scientific discoveries in the field of gene and cell therapy, some diseases still have no effective treatment. Advances in genetic engineering methods have enabled the development of effective gene therapy methods for various diseases based on adeno-associated viruses (AAVs). Today, many AAV-based gene therapy medications are being investigated in preclinical and clinical trials, and new ones are appearing on the market. In this article, we present a review of AAV discovery, properties, different serotypes, and tropism, and a following detailed explanation of their uses in gene therapy for disease of different organs and systems.

_Abstract reproduced under CC-BY (publisher license, via OpenAlex)._

Topics: [Gene & Cell Therapy](https://space-kitty.com/topics/gene-cell-therapy)

Cited in dossiers:
- [Gene & Cell Therapy: State of the Field (October 2026)](https://space-kitty.com/dossiers/gene-cell-therapy)

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