# Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer

Review · Elbadawy M, Usui T, Yamawaki H, Sasaki K

- Archive id: doi:10.3390/ijms20092340
- Published: 2019-05-11
- Venue: International journal of molecular sciences
- DOI: https://doi.org/10.3390/ijms20092340
- PMID: 31083525
- PMCID: PMC6539579
- Citations: 192
- Source URL: https://doi.org/10.3390/ijms20092340
- PDF: https://europepmc.org/articles/PMC6539579/pdf
- Provenance: europepmc

## Abstract

Myc is a nuclear transcription factor that mainly regulates cell growth, cell cycle, metabolism, and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can become a promising therapeutic target molecule in cancer. Cancer stem cells (CSCs) are known to be responsible for the therapeutic resistance. In the previous study, we demonstrated that c-Myc mediates drug resistance of colorectal CSCs using a patient-derived primary three-dimensional (3D) organoid culture. In this review, we mainly focus on the roles of c-Myc-related signaling in the regulation of CSCs, chemotherapy resistance, and colorectal cancer organoids. Finally, we introduce the various types of c-Myc inhibitors and propose the possibility of c-Myc as a therapeutic target against colorectal cancer.

_Abstract reproduced under CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)._

Topics: [Organoids & Organ-on-Chip](https://space-kitty.com/topics/organoids)

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