# Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development

Review · Schmidt C, Schnierle BS

- Archive id: doi:10.3390/pathogens12010138
- Published: 2023-01-13
- Venue: Pathogens (Basel, Switzerland)
- DOI: https://doi.org/10.3390/pathogens12010138
- PMID: 36678486
- PMCID: PMC9863218
- Citations: 65
- Source URL: https://doi.org/10.3390/pathogens12010138
- PDF: https://europepmc.org/articles/PMC9863218/pdf
- Provenance: europepmc

## Abstract

The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen expression by amplification of the antigen-encoding RNA. RNA design, RNA delivery, and the innate immune responses induced by RNA will be reviewed.

_Abstract reproduced under CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)._

Topics: [mRNA Therapeutics & Cancer Vaccines](https://space-kitty.com/topics/mrna-cancer-vaccines)

---
Space Kitty Archive · https://space-kitty.com · API: https://space-kitty.com/api/v1 · MCP: https://space-kitty.com/mcp · Premium: $0.20/request via x402 (Base Sepolia (testnet)). Metadata: arXiv (CC0), OpenAlex (CC0), Europe PMC (CC BY/CC0 works), ClinicalTrials.gov.