# Base editing reversal of radiation sensitivity in NHEJ1 immunodeficiency

Article · Kadirkamanathan R, Preece R, Woodbine L, Korneeva E, Lazareva A, Ip W, Qasim W

- Archive id: doi:10.70962/jhi.20260068
- Published: 2026-09-03
- Venue: Journal of human immunity
- DOI: https://doi.org/10.70962/jhi.20260068
- PMID: 42690170
- PMCID: PMC13540376
- Citations: 0
- Source URL: https://doi.org/10.70962/jhi.20260068
- PDF: https://europepmc.org/articles/PMC13540376/pdf
- Provenance: europepmc

## Abstract

Inherited defects of DNA double-stranded break (DSB) repair can result in radiosensitive/radiation-sensitive (RS) SCID (RS-SCID). We applied base editing to reverse NHEJ1 mutations in patient fibroblasts, exemplifying how this technology can help interrogate RS sequence variants.

_Abstract reproduced under CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)._

Topics: [CRISPR & Gene-Editing Therapies](https://space-kitty.com/topics/gene-editing-therapies)

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