# Functional gradients of the cerebellum

Article · Guell X, Schmahmann JD, Gabrieli J, Ghosh SS

- Archive id: doi:10.7554/elife.36652
- Published: 2018-08-14
- Venue: eLife
- DOI: https://doi.org/10.7554/elife.36652
- PMID: 30106371
- PMCID: PMC6092123
- Citations: 442
- Source URL: https://doi.org/10.7554/elife.36652
- PDF: https://europepmc.org/articles/PMC6092123/pdf
- Provenance: europepmc

## Abstract

A central principle for understanding the cerebral cortex is that macroscale anatomy reflects a functional hierarchy from primary to transmodal processing. In contrast, the central axis of motor and nonmotor macroscale organization in the cerebellum remains unknown. Here we applied diffusion map embedding to resting-state data from the Human Connectome Project dataset (n = 1003), and show for the first time that cerebellar functional regions follow a gradual organization which progresses from primary (motor) to transmodal (DMN, task-unfocused) regions. A secondary axis extends from task-unfocused to task-focused processing. Further, these two principal gradients revealed novel functional properties of the well-established cerebellar double motor representation (lobules I-VI and VIII), and its relationship with the recently described triple nonmotor representation (lobules VI/Crus I, Crus II/VIIB, IX/X). Functional differences exist not only between the two motor but also between the three nonmotor representations, and second motor representation might share functional similarities with third nonmotor representation.

_Abstract reproduced under CC-BY (article license as recorded by Europe PMC; abstract reproduced unmodified apart from markup removal)._

Topics: [Connectomics & Brain Mapping](https://space-kitty.com/topics/connectomics)

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