# Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery

Clinical trial · Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan

- Archive id: nct:NCT00660894
- Published: 2008-04-17
- Venue: ClinicalTrials.gov
- ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT00660894
- Source URL: https://clinicaltrials.gov/study/NCT00660894
- Provenance: clinicaltrials

## Abstract

RATIONALE: Drugs used in chemotherapy, such as tegafur-uracil, leucovorin, and S-1, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving tegafur-uracil together with leucovorin is more effective than giving S-1 in treating patients with stage III colon cancer. PURPOSE: This randomized phase III trial is studying giving tegafur-uracil together with leucovorin to see how well it works compared with giving S-1 in treating patients with stage III colon cancer that has been completely removed by surgery.

_Abstract reproduced under ClinicalTrials.gov (U.S. National Library of Medicine), data processed 2026-10-29T09:00:05; modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters._

## Trial details

- status: COMPLETED
- phase: PHASE3
- study type: INTERVENTIONAL
- enrollment: 1535
- sponsor: Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
- conditions: Colorectal Cancer
- interventions: DRUG: folinate calcium; DRUG: tegafur-uracil; DRUG: tegafur-gimeracil-oteracil potassium
- start date: 2008-04-01
- primary completion date: 2012-06-01
- has results: false
- data source: ClinicalTrials.gov
- data processed: 2026-10-29T09:00:05
- modifications: selected fields only; whitespace normalized; brief summary truncated to 2,000 characters

Topics: [Gene & Cell Therapy](https://space-kitty.com/topics/gene-cell-therapy)

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